Copper-Catalyzed Coupling of Hydroxylamines with Aryl Iodides

Significance

Copper-catalyzed modified Ulmann condensation is now one of the best ways for the preparation of arenes bearing nitrogen-containing substituents. This is the first report of a Cu-catalyzed N-arylation of hydroxylamines. N-Arylhydroxylamines are extremely valuable intermediates for the synthesis of various nitrogen-containing compounds of use for the preparation of pharmaceutical agents. This method allows an easy synthesis of orthogonally protected N-arylhydroxyl­amines, opening direct ways for their further functionalization.