Synfacts

Issue 01 · January 2022

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SYNFORM ISSUE 2022/01 FREE ACCESS

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Synthesis of Natural Products and Potential Drugs
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Synthesis of (+)-Cyclobutastellettolide B FREE ACCESS

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0002
Synthesis of MK-4688

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0003
Synthesis of Reldesemtiv

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0004
Total Synthesis of (+)-Toxicodenane A

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0005
Synthesis of (–)-Taxol

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0006
Synthesis of Dengue Virus Inhibitor JNJ-A07 FREE ACCESS

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0007
Synthesis of GDC-4379

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0008
Total Synthesis of (–)-Cephanolide A

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0009
Total Synthesis of (+)-Pileamartine A

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0010
Synthesis of BMS-986278

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0011
Synthesis of (–)-Chrodrimanin C and (–)-Verruculide A

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0012
Total Synthesis of (±)-Muscone FREE ACCESS

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Synthesis of Heterocycles
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0013
Synthesis of Halogenated Azidopyridines

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0014
Pd(II)-Catalyzed Synthesis of Functionalized Dihydrobenzoxazines and a Functionalized Tricyclic System

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0015
Machine-Learning-Based Approach to Expanding SAR Exploration

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0016
Single-Electron Reduction of Sulfonium Salts for the Generation of Nonstabilized Alkyl Radicals FREE ACCESS

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0017
Regioselective Late-Stage Alkylation of Complex Molecules

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0018
Sulfonium-Salt Based Trifluoromethylating Reagent Permits Multiple Reactivity Paradigms

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0019
One-Step Synthesis of Pyrazolo[1,5-a]pyrimidines by a Copper-Catalyzed Dehydrogenation/[3+3] Annulation

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0020
Gold-Catalyzed Synthesis of Versatile Heterospirocycles

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0021
Synthesis of Seven-Membered N,O-Heterocycles by Using a Palladium(sulfoxide) White-Type Catalyst

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0022
Indole Synthesis through Reductive Cyclization of 2-Nitrostyrenes with Phenyl Formate as a CO Surrogate

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Synthesis of Materials and Unnatural Products
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Cavitands with Controllable Side Walls

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0024
Stairway to Thienoacenes

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0025
Molecular Bannisters

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Remarkably Stable Boron-Containing Organic Diradicaloids

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0027
Double the Heterohelicene Fun with Borons and Nitrogens

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0028
Well-Defined Si_xGe_yClusters

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0029
Versatile Aryl Halide Hydroxylation

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0030
Double π-Extended Helicenes via an Unsymmetrical Twofold Scholl Cyclization

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0031
Synthesis of Multisubstituted Imidazolo[4,5-d]pyridazine Fused Ring System

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0032
Half-Fused Condensation Polymers

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0033
Synthesis of a Rigid Nanopillar

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0034
Synthesis of α-Aryl Azahelicene

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Metals in Synthesis
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0035
Synthesis of Sulfinamides, Sulfonimidamides, and Sulfonamides: A One-Pot Procedure to Rule them All FREE ACCESS

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0036
Tied Together: meta-Selective C–H Alkenylation of Pyridines Enabled by a Bifunctional NHC Ligand

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0037
Enantioselective Cobalt-Catalyzed Alkene Hydroalkylation FREE ACCESS

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0038
Manganese Enables the Dehydrogenative Silylation of Alkenes Instead of Simple Hydrosilylation

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0039
Rhodium(III)-Catalyzed Diastereoselective Oxyamination of 1,3-Dienes

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0040
Synthesis of Diarylamines by Reductive Cross-Coupling of Nitroarenes and Aryl Boronic Acids

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0041
A Dual Ni/Cu Catalytic System for the Linear Selective Hydroalkylation of Vinyl Arenes

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0042
Quantitative Carbon Isotope Labeling of Carboxylic Acids

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0043
Cobalt Does What Nickel Cannot Do: Cobalt-Catalyzed Enantiospecific Vinylation of Allylic Alcohols

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0044
Rhodium-Catalyzed [2+2+1] Hydrative Annulation of 1,6-Enynes and Terminal Alkynes

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0045
Linking Carbon and Silicon Electrophiles: C(sp³)–Si Cross-Coupling of Alkyl Bromides and Vinyl Chlorosilanes

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0046
Catalytic 1,2-Difunctionalization of Alkenes with Alkyl Iodides and Isocyanides under Visible-Light Irradiation

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0047
The Mastering of Triplets: A Triplet-Energy-Transfer Strategy for the Synthesis of 1- and 2-Azetines

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0048
Photoredox-Catalyzed Decarboxylative Cross-Coupling of C–O Bonds via a Carbocation

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0049
Gold-Catalyzed Asymmetric [3,3]-Sigmatropic Rearrangement of Vinyl Sulfoxides and Propargyl Silane

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0050
Esters in a Squeeze: A Bifunctional Copper Catalyst Effects the Hydrogenation of Esters to Alcohols

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0051
Nickel-Catalyzed Hydrocarboxylation and Enantioselective Transfer Hydrogenation of Alkynes

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0052
Nickel-Catalyzed Enantioselective Allylic Alkylation of Phosphinates

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0053
Enantioselective Iron-Catalyzed Formal [4+2] Cycloaddition

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0054
It’s All About Boron: Access to Boron-Stereogenic Compounds by a Desymmetrizing Click Reaction

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0055
Back to the Carbonyl: Iron-Catalyzed Degradation of Alcohols by C–C Bond Cleavage

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0056
Palladium-Catalyzed Arylative Ring Expansion of Fused Bicyclic Vinyl Cyclopropanes

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0057
Anti-Markovnikov Hydroamination of Alkenes Enabled by Dual Phospine/Photoredox Catalysis

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0058
Enantioselective Difunctionalization of 1,3-Enynes via Palladium-Catalyzed Tandem Coupling/Suzuki Cascade

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0059
You Only React Twice: Synthesis of 2-Iminothietanes by Twofold Methylene Insertion to Isothiocyanates

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0060
Palladium- and Copper-Catalyzed Synthesis of 1,3-Dienes

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0061
Synthesis of Enantioenriched Morpholines via Rhodium-Catalyzed Asymmetric Hydrogenation

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0062
The Bönnemann–Wakatsuki Pyridine Synthesis FREE ACCESS

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0063
Gold(III)-Catalyzed Hydration of Alkynes FREE ACCESS

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Polymer-Supported Synthesis
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0065
Photoinduced Cross-Coupling with a Supported Iridium–Nickel Bimetallic Catalyst FREE ACCESS

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0066
Polyoxomolybdate-Based Chromium(III) Catalyst for the Synthesis of Disulfides from Boronic Acids

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0067
Humic-Acid-Supported Platinum Single Atoms for Regioselective Alkene Hydrosilylation

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0068
Olefination of Aryl Aldehydes with Ethyl Diazoacetate on a Carbon-Supported Co/Cu Bimetal Catalyst

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0069
C–H Alkylation and Arylation of 2-Picolinamides on an Immobilized Bipyridine–Manganese Complex

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0070
C(sp²)–H Halogenation and Arylation on a Heterogeneous Polymeric NHC–Palladium Catalyst

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0071
Covalent Organic Framework Catalysts for Carboxylation of Terminal Alkynes

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0072
Synthesis of Quinoline-3-carbonitriles on a Cobalt Ferrate–Graphene Quantum Dot Nanocomposite

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0073
Suzuki–Miyaura Cross-Coupling by a Pd–Schiff Base Complex Immobilized on a Hypercrosslinked Polymer FREE ACCESS

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0074
A Recyclable Alternative to DMF Solvent for Syntheses of Benzylic Azides and 1,2,3-Triazoles

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Organo- and Biocatalysis
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0075
Efficient Synthesis of Molnupiravir by a Biocatalytic Cascade Involving a Phosphate-Recycling Strategy FREE ACCESS

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0076
Directed-Evolution-Modified Class I Aldolase Catalyzes Asymmetric Michael Addition of Nitromethane to Enals

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0077
Enzyme-Bound Iminium Ion Intermediate for Cyclopropanation of Cinnamaldehydes

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0078
Visible-Light-Driven Organocatalytic Hydrosilylation to form Polycarbosilanes with Tunable Structures

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0079
Biocatalyst Permits Enantioselective Amine Insertion into Lactone Carbenes through Dual Activation

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0080
Visible-Light-Mediated Decarboxylative Conjugate Olefination

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0081
Asymmetric Cyclopropanation of (E)-Chalcones with Benzyl Bromides by Organoselenium Catalysis

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0082
Chiral Brønsted Acid-Catalyzed Dearomatization Reactions by Direct Activation of Ynamides

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0083
Asymmetric Photoinduced 1,4-Selective Allylation of α,β-Unsaturated Aldehydes through Organocatalysis

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0084
Phosphine-Catalyzed Three-Component Alkyne Hydrovinylation

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Chemistry in Medicine and Biology
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0085
The Next Generation Lincosamide: Iboxamycin FREE ACCESS

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0086
BromoTag – A ‘Bump-and-Hole’ PROTAC System

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0087
Biosynthetic Glycan Labeling

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0088
Development of a Selective PI3Kγ Inhibitor

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0089
Aristoquinoline – A nAChRally Occurring Antagonist

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0090
Glutathione-Sensitive Imaging and Targeted Drug Delivery

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0091
Orally Dosed Lipid-Lowering Peptide

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0092
Expanding the Toolbox of Synthetic Genetics

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0093
Photoswitchable Anion Carriers

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0094
Umibecestat, A Highly Selective β‑Secretase (BACE1) Inhibitor

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0095
Presaccharothriolide Z, an (E)-Enone-Containing, 10-Membered Macrolactone

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0096
No Strain-No Gain: Adducts of Strain-Release Povarov Reaction Against Multidrug-Resistant Persister Bacteria

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0097
Hygromycin A Finds a New Purpose FREE ACCESS

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Peptide Chemistry
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0099
Photochemical Functionalization of Peptides on a Solid Support

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0100
C–H Activation/Lossen Rearrangement/Annulation to Access Trifluoromethylated Amino Acids

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0101
Palladium-Catalyzed Multiple S-Arylation for the Synthesis of Macrocyclic Peptides FREE ACCESS

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0102
Nickel-Catalyzed Alkenylation and Arylation of α-C-Tosyl Peptides with C(sp²) Triflates/Halides

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0103
Electrochemical Synthesis of Amino Acid Amides Catalyzed by TEMPO

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0104
Palladium-Catalyzed Olefination of Tryptophan Residues in Peptides

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0105
Organocatalytic Synthesis of Chiral α-Halo-α-Aryl-β^2,2-Amino Acid Derivatives

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0106
Molybdenum-Catalyzed Indane-Based Amino Acid/Peptide Synthesis

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0107
Electrochemical Synthesis of N-Boc-α-Amino Acids

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0108
Racemization-Free Dipeptide Synthesis by Using a Chloro(triphenyl)phosphonium Intermediate

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0109
N-Propyl-1H-pyrazole-1-carboximidamide for the Synthesis of N^ω-Propylarginine-Containing Dipeptides FREE ACCESS

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Flow Chemistry
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0111
Enantioselective Scandium Catalyzed C–C Bond-Forming Reactions in Continuous Flow

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0112
A Scalable Flow System for the Diels–Alder Reaction of Phenylacetylenes with Dicyclopentadiene

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0113
Flow-Type C–H Amidation to Afford α-Amino Acid Derivatives

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0114
Electrochemical Cross-Coupling of Arenes under Flow Conditions

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