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Synfacts 2008(12): 1244-1244  
DOI: 10.1055/s-0028-1087288
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Potent Inhibitor of HCV NS3/4A Protease

Contributor(s): Philip Kocienski, Zofia Komsta
N. J. Liverton*
Merck Research Laboratories, West Point, USA
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

Using molecular modeling methods, a potent inhibitor of the hepatitis C virus (HCV) NS3/4A protease was designed. Its in vitro activity, selectivity and pharmacokinetic profile in rats showed very promising results in comparison with some other NS3/4A protease inhibitors already in clinical development.