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Synfacts 2010(2): 0214-0214
DOI: 10.1055/s-0029-1219057
DOI: 10.1055/s-0029-1219057
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Pd(II)-Catalyzed ortho-Hydroxylation of Benzoic Acids with 1 atm O2 or Air
Y.-H. Zhang, J.-Q. Yu*
The Scripps Research Institute, La Jolla, USA
Further Information
Publication History
Publication Date:
21 January 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219057-1.jpg)
Significance
Activation of inert C-H bonds is an important task in organic synthesis. Highly selective Pd-catalyzed ortho-hydroxylation of potassium benzoates using O2 as an oxidant gives good to excellent yields of substituted salicylic acid salts under non-acidic conditions, offering also excellent functional group compatibility.