Mechanistic Studies and Reaction Calorimetry Enable Safe Scale-up of a Reduction with NaBH4 and TFA

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Synfacts 2024; 20(07): 0763
DOI: 10.1055/s-0043-1774883

Innovative Drug Discovery and Development

Mechanistic Studies and Reaction Calorimetry Enable Safe Scale-up of a Reduction with NaBH₄ and TFA

Contributor(s):

Antonia F. Stepan (Roche)

,

Brittany M. Armstrong (MSD)

sodium borohydride - reduction - process safety - mechanistic studies - reaction calorimetry

Article published online:
14 June 2024

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany