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DOI: 10.1055/s-0043-1775399
Enantioselective Synthesis of Cyclobutylboronates
This work is supported by the National Natural Science Foundation (Grant 22371189, 22001180 and 22301194) and the Thousand Young Talents Program of China (Grant 15-YINGXIA).
Abstract
Cyclobutane derivatives are important motifs in natural products and bioactive compounds. Owing to their inherent strain, the asymmetric synthesis of cyclobutanes remains a formidable challenge. With the development of various stereospecific transformations of alkylboronic esters, chiral cyclobutylboronates are expected to serve as promising synthetic intermediates for accessing chiral cyclobutane derivatives. However, obtaining highly enantioenriched cyclobutylboronates poses a daunting task in the field of organic synthesis. In this context, we highlight recent significant advances in the synthesis of chiral cyclobutylboronates.
1 Introduction
2 Enantioselective Borylation of Cyclobutenes
3 Enantioselective Borylation of Cyclobutanes
4 Other Methods
5 Conclusions
Publication History
Received: 11 July 2024
Accepted after revision: 12 August 2024
Article published online:
10 October 2024
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