Thrombosis and Haemostasis

Issue 08 · 1999

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Research Article
165
Mann, Kenneth G.: Biochemistry and Physiology of Blood Coagulation

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175
Ruf, Wolfram; Mueller, Barbara M.: Tissue Factor Signaling

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183
Prydz, Hans; Camerer, Eric; Røttingen, John-Arne; Wiiger, Merete Thune; Gjernes, Elisabet: Cellular Consequences of the Initiation of Blood Coagulation

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193
Fay, Philip J.: Regulation of Factor VIIIa in the Intrinsic Factor Xase

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201
Kaufman, Randal J.; Pipe, Steven W.: Regulation of Factor VIII Expression and Activity by von Willebrand Factor

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209
Mertens, Koen; Celie, Patrick H.N.; Kolkman, Joost A.; Lenting, Peter J.: Factor VIII-Factor IX Interactions: Molecular Sites Involved in Enzyme-Cofactor Complex Assembly

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218
Bajaj, S. Paul: Region of Factor IXa Protease Domain that Interacts with Factor VIIIa: Analysis of Select Hemophilia B Mutants

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226
Schmaier, Alvin H.; Røjkjær, Rasmus; Shariat-Madar, Zia: Activation of the Plasma Kallikrein/Kinin System on Cells: A Revised Hypothesis

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234
Walsh, Peter N.: Platelets and Factor XI Bypass the Contact System of Blood Coagulation

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243
Bouma, Bonno N.; Meijers, Joost C.M.: Fibrinolysis and the Contact System: A Role for Factor XI in the Down-Regulation of Fibrinolysis

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251
Esmon, Charles T.; Xu, Jun; Gu, Jian-ming; Qu, Dongfeng; Laszik, Zolton; Ferrell, Gary; Stearns-Kurosawa, Deborah J.; Kurosawa, Shichiro; Taylor, Fletcher B.; Esmon, Naomi L.: Endothelial Protein C Receptor

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259
Collen, Désiré: The Plasminogen (Fibrinolytic) System

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271
Doolittle, Russell F.; Spraggon, Glen; Everse, Stephen J.: Crystal Structures of Fragments D and Double-D from Fibrinogen and Fibrin

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277
Weisel, John W.; Veklich, Yuri; Collet, Jean-Philippe; Francis, Charles W.: Structural Studies of Fibrinolysis by Electron and Light Microscopy

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283
Matsuda, Michio; Sugo, Teruko; Yoshida, Nobuhiko; Terukina, Shigeharu; Yamazumi, Kensuke; Niwa, Kazuki; Maekawa, Hisato: Structure and Function of Fibrinogen: Insights from Dysfibrinogens

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291
Chapman, Harold A.; Wei, Ying; Simon, Daniel I.; Waltz, David A.: Role of Urokinase Receptor and Caveolin in Regulation of Integrin Signaling

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298
Blasi, Francesco: Proteolysis, Cell Adhesion, Chemotaxis, and Invasiveness Are Regulated by the u-PA-u-PAR-PAI-1 System

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305
Koshelnick, Yuri; Ehart, Monika; Stockinger, Hannes; Binder, Bernd R.: Mechanisms of Signaling through Urokinase Receptor and the Cellular Response

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312
Kaushansky, Kenneth: Thrombopoietin: From Theory to Reality

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318
Shattil, Sanford J.: Signaling Through Platelet Integrin αIIbβ3: Inside-out, Outside-in, and Sideways

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326
Coller, Barry S.: Binding of Abciximab to αVβ3 and Activated αMβ2 Receptors: With a Review of Platelet-Leukocyte Interactions

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337
Bray, Paul F.: Integrin Polymorphisms as Risk Factors for Thrombosis

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345
Law, Debbie A.; Nannizzi-Alaimo, Lisa; Cowan, Kyra J.; Prasad, K. S. Srinivasa; Ramakrishnan, Vanitha; Phillips, David R.: Signal Transduction Pathways for Mouse Platelet Membrane Adhesion Receptors

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353
Coughlin, Shaun R.: Protease-Activated Receptors and Platelet Function

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357
Andrews, Robert K.; Shen, Yang; Gardiner, Elizabeth E.; Dong, Jing-fei; López, José A.; Berndt, Michael C.: The Glycoprotein Ib-IX-V Complex in Platelet Adhesion and Signaling

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365
Watson, Steve P.: Collagen Receptor Signaling in Platelets and Megakaryocytes

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377
Oda, Atsushi; Miyakawa, Yoshitaka; Druker, Brian J.; Ozaki, Katsutoshi; Ohashi, Hideya; Kato, Takashi; Miyazaki, Hiroshi; Handa, Makoto; Ikebuchi, Kenji; Ikeda, Yasuo: Thrombopoietin-Induced Signal Transduction and Potentiation of Platelet Activation

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385
Fox, Joan E. B.: On the Role of Calpain and Rho Proteins in Regulating Integrin-induced Signaling

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392
Hartwig, John H.; Barkalow, Kurt; Azim, Anser; Italiano, Joe: The Elegant Platelet: Signals Controlling Actin Assembly

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399
Ma, Alice D.; Abrams, Charles S.: Pleckstrin Homology Domains and Phospholipid-Induced Cytoskeletal Reorganization

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407
Manganiello, V. C.; Degerman, E.: Cyclic Nucleotide Phosphodiesterases (PDEs): Diverse Regulators of Cyclic Nucleotide Signals and Inviting Molecular Targets for Novel Therapeutic Agents

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412
Haslam, Richard J.; Dickinson, Natalie T.; Jang, Elliott K.: Cyclic Nucleotides and Phosphodiesterases in Platelets

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424
Rybalkin, Sergei D.; Bornfeldt, Karin E.: Cyclic Nucleotide Phosphodiesterases and Human Arterial Smooth Muscle Cell Proliferation

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435
Ikeda, Yasuo: Antiplatelet Therapy Using Cilostazol, a Specific PDE3 Inhibitor

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439
Warkentin, Theodore E.: Heparin-Induced Thrombocytopenia: A Clinicopathologic Syndrome

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448
Visentin, Gian Paolo: Heparin-Induced Thrombocytopenia: Molecular Pathogenesis

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457
Greinacher, Andreas: Treatment of Heparin-Induced Thrombocytopenia

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468
Nurden, Alan T.: Inherited Abnormalities of Platelets

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481
Hynes, Richard O.; Hodivala-Dilke, Kairbaan M.: Insights and Questions Arising from Studies of a Mouse Model of Glanzmann Thrombasthenia

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486
Drohan, William N.; Cervenakova, Larisa: Safety of Blood Products: Are Transmissible Spongiform Encephalopathies (Prion Diseases) a Risk?

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494
Chamberland, Mary E.: Surveillance for Bloodborne Infections

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500
Gill, Joan Cox: The Role of Genetics in Inhibitor Formation

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505
Lollar, Pete: Characterization of Factor VIII B-Cell Inhibitory Epitopes

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509
Reding, M.T.; Wu, H.; Krampf, M.; Okita, D.K.; Diethelm-Okita, B.M.; Key, N.S.; Conti-Fine, B.M.: CD4⁺ T Cell Response to Factor VIII in Hemophilia A, Acquired Hemophilia, and Healthy Subjects

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516
Lee, Christine: Recombinant Clotting Factors in the Treatment of Hemophilia

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525
Ljung, Rolf C. R.: Prophylactic Infusion Regimens in the Management of Hemophilia

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531
Hedner, Ulla: Treatment of Patients with Factor VIII and Factor IX Inhibitors with Special Focus on the Use of Recombinant Factor VIIa

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540
Herzog, Roland W.; High, Katherine A.: Adeno-Associated Virus-Mediated Gene Transfer of Factor IX for Treatment of Hemophilia B by Gene Therapy

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547
Kochanek, Stefan: Development of High-Capacity Adenoviral Vectors for Gene Therapy

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552
Naldini, Luigi: In Vivo Gene Delivery by Lentiviral Vectors

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555
Greengard, Judith S.; Jolly, Douglas J.: Animal Testing of Retroviral-Mediated Gene Therapy for Factor VIII Deficiency

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562
Zhang, Wei-Wei; Josephs, Steven F.; Zhou, Jiemin; Fang, Xiangming; Alemany, Ramón; Balagué, Cristina; Dai, Yifan; Ayares, David; Prokopenko, Elena; Lou, Yan-Chun; Sethi, Erica; Hubert-Leslie, Debbie; Kennedy, Mark; Ruiz, Lulio; Rockow-Magnone, Shayna: Development And Application Of A Minimal-Adenoviral Vector System For Gene Therapy Of Hemophilia A

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572
Lusher, Jeanne M.: Gene Therapy for Hemophilia A and B: Patient Selection and Follow-up, Requirements for a Cure

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576
Ruggeri, Zaverio M.: Structure and Function of von Willebrand Factor

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585
Ginsburg, David: Molecular Genetics of von Willebrand Disease

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592
Furlan, Miha; Lämmle, Bernhard: Von Willebrand Factor in Thrombotic Thrombocytopenic Purpura

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601
Bertina, Rogier M.: Molecular Risk Factors for Thrombosis

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610
Rosendaal, F.R.: Risk Factors for Venous Thrombotic Disease

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620
Ginsberg, Jeffrey S.: Thromboembolism and Pregnancy

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626
Koh, Kwang Kon; Horne, McDonald K.; Cannon, Richard O.: Effects of Hormone Replacement Therapy on Coagulation, Fibrinolysis, and Thrombosis Risk in Postmenopausal Women

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634
Brenner, Benjamin: Inherited Thrombophilia and Pregnancy Loss

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641
Lockshin, Michael D.: Pregnancy Loss in the Antiphospholipid Syndrome

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649
Rand, Jacob H.; Wu, Xiao-Xuan: Antibody-Mediated Disruption of the Annexin-V Antithrombotic Shield: A New Mechanism for Thrombosis in the Antiphospholipid Syndrome

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656
Roubey, Robert A. S.: Immunology of the Antiphospholipid Syndrome: Antibodies, Antigens, and Autoimmune Response

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662
Bovill, Edwin G.; Hasstedt, Sandra J.; Leppert, Mark F.; Long, George L.: Hereditary Thrombophilia as a Model for Multigenic Disease

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667
Lowe, Gordon D.O.; Rumley, Ann: Use Of Fibrinogen and Fibrin D-Dimer in Prediction of Arterial Thrombotic Events

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673
Dempfle, Carl-Erik: The Use of Soluble Fibrin in Evaluating the Acute and Chronic Hypercoagulable State

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684
Toh, Cheng Hock: APTT Revisited: Detecting Dysfunction in the Hemostatic System Through Waveform Analysis

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688
Brill-Edwards, Patrick; Lee, Agnes: D-Dimer Testing in the Diagnosis of Acute Venous Thromboembolism

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695
Levi, Marcel; de Jonge, Evert; van der Poll, Tom; ten Cate, Hugo: Disseminated Intravascular Coagulation

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706
Müller-Berghaus, Gert; ten Cate, Hugo; Levi, Marcel: Disseminated Intravascular Coagulation: Clinical Spectrum and Established as well as New Diagnostic Approaches

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713
ten Cate, Hugo; Timmerman, Janneke J.; Levi, Marcel: The Pathophysiology of Disseminated Intravascular Coagulation

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718
Maruyama, Ikuro: Recombinant Thrombomodulin and Activated Protein C in the Treatment of Disseminated Intravascular Coagulation

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722
Gimbrone, Michael A.: Endothelial Dysfunction, Hemodynamic Forces, and Atherosclerosis

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727
Freyssinet, Jean-Marie; Toti, Florence; Hugel, Bénédicte; Gidon-Jeangirard, Carole; Kunzelmann, Corinne; Carmen Martínez, M.; Meyer, Dominique: Apoptosis in Vascular Disease

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736
Libby, Peter; Mach, François; Schönbeck, Uwe; Bourcier, Todd; Aikawa, Masanori: Regulation of the Thrombotic Potential of Atheroma

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742
Samad, Fahumiya; Loskutoff, David J.: Hemostatic Gene Expression and Vascular Disease in Obesity: Insights from Studies of Genetically Obese Mice

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748
Friesel, R.; Maciag, T.: Fibroblast Growth Factor Prototype Release and Fibroblast Growth Factor Receptor Signaling

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755
Dejana, Elisabetta; Bazzoni, Gianfranco; Lampugnani, Maria Grazia: The Role of Endothelial Cell-to-Cell Junctions in Vascular Morphogenesis

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762
Yee, Karen O.; Schwartz, Stephen M.: Why Atherosclerotic Vessels Narrow: The Fibrin Hypothesis

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772
Helisch, Armin; Anthony Ware, J.: Therapeutic Angiogenesis in Ischemic Heart Disease

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781
Altieri, Dario C.: Regulation of Leukocyte-Endothelium Interaction by Fibrinogen

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787
Cerletti, Chiara; Evangelista, Virgilio; de Gaetano, Giovanni: P-Selectin-β2-Integrin Cross-Talk: A Molecular Mechanism For Polymorphonuclear Leukocyte Recruitment At The Site Of Vascular Damage

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794
Barry, Orla P.; FitzGerald, Garret A.: Mechanisms of Cellular Activation by Platelet Microparticles

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801
Taubman, Mark B.; Giesen, Peter L.A.; Schecter, Alison D.; Nemerson, Yale: Regulation of the Procoagulant Response to Arterial Injury

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806
Koyama, Hiroyuki; Eric Olson, N.; Reidy, Michael A.: Cell Signaling in Injured Rat Arteries

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810
Berk, Bradford C.: Redox Signals that Regulate the Vascular Response to Injury

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818
Humphries, Steve E.; Luong, Le-Anh; Montgomery, Hugh E.; Day, Ian N.M.; Mohamed-Ali, Vidya; Yudkin, John S.: Gene-Environment Interaction in the Determination of Levels of Plasma Fibrinogen

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826
Tracy, Russell P.: Epidemiological Evidence for Inflammation in Cardiovascular Disease

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832
Juhan-Vague, I.; Alessi, M.C.: Regulation of Fibrinolysis in the Development of Atherothrombosis: Role of Adipose Tissue

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837
Lijnen, H.R.; Collen, D.: Matrix Metalloproteinase System Deficiencies and Matrix Degradation

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846
Shapiro, Steven D.: Diverse Roles of Macrophage Matrix Metalloproteinases in Tissue Destruction and Tumor Growth

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850
Hartwell, Daqing W.; Wagner, Denisa D.: New Discoveries with Mice Mutant in Endothelial and Platelet Selectins

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858
Degen, Jay L.: Hemostatic Factors and Inflammatory Disease

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865
Sato, Thomas N.: Gene Trap, Gene Knockout, Gene Knock-In, and Transgenics in Vascular Development

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870
Bates, Shannon M.; Hirsh, Jack: Treatment of Venous Thromboembolism

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PDF (58 kb)
878
Anderson, David R.; Wells, Philip S.: Improvements in the Diagnostic Approach for Patients with Suspected Deep Vein Thrombosis or Pulmonary Embolism

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PDF (87 kb)
887
Kearon, Clive: Initial Treatment of Venous Thromboembolism

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892
Prins, Martin H.; Hutten, Barbara A.; Koopman, Maria M.W.; Büller, Harry R.: Long-Term Treatment of Venous Thromboembolic Disease

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899
Goldhaber, Samuel Z.: Venous Thromboembolism Prophylaxis in Medical Patients

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902
Dahl, Ola E.: Mechanisms of Hypercoagulability

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907
Torbicki, Adam: Imaging Venous Thromboembolism with Emphasis on Ultrasound, Chest CT, Angiography and Echocardiography

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913
Thompson, Gale E.: Anticoagulation in the Setting of Epidural or Spinal Anesthesia/Analgesia

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918
Pineo, G.F; Hull, R.D.: Prophylaxis of Venous Thromboembolism Following Orthopedic Surgery: Mechanical and Pharmacological Approaches and the Need for Extended Prophylaxis

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925
Agnelli, Giancarlo: Prevention of Venous Thromboembolism After Neurosurgery

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931
Bounameaux, Henri: Integrating Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism

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938
del Zoppo, Gregory J.: Antithrombotic Treatments in Acute Ischemic Stroke

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947
Hettiarachchi, Rohan J.K.; Smorenburg, Susanne M.; Ginsberg, Jeffrey; Levine, Mark; Prins, Martin H.; Büller, Harry R.: Do Heparins Do More than Just Treat Thrombosis? The Influence of Heparins on Cancer Spread

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953
Gulba, Dietrich C.: Do Interventions Provide Additional Benefit to Drug Treatment of Acute Coronary Syndromes? A Call for a Reserved, Watchful Approach

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962
May, Andreas E.; Neumann, Franz-Josef; Preissner, Klaus T.: The Relevance of Blood Cell-Vessel Wall Adhesive Interactions for Vascular Thrombotic Disease

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971
van de Loo, Jürgen C.W.: Historical Perspectives on Thrombolytic Therapy

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974
Weitz, Jeffrey I.; Stewart, Ronald J.; Fredenburgh, James C.: Mechanism of Action of Plasminogen Activators

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983
Hacke, Werner; Ringleb, Peter; Stingele, Robert: Thrombolysis in Acute Cerebrovascular Disease: Indications and Limitations

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987
Kandarpa, Krishna: Catheter-Directed Thrombolysis of Peripheral Arterial Occlusions and Deep Vein Thrombosis

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PDF (122 kb)
997
Badimon, Juan Jose; Zaman, Azfar; Helft, Gerard; Fayad, Zahi; Fuster, Valentin: Acute Coronary Syndromes: Pathophysiology and Preventive Priorities

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