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Synfacts 2006(2): 0102-0102
DOI: 10.1055/s-2005-921779
DOI: 10.1055/s-2005-921779
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Psymberin/Irciniastatin A
X. Jiang, J. Garcia-Fortanet, J. K. De Brabander*
The University of Texas Medical Center at Dallas, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Januar 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200602/lookinside/thumbnails/10.1055-s-2005-921779-1.jpg)
Significance
Irciniastatin A and Psymberin were isolated independently by the groups of Pettit and Crews in 2004 from the sponges Ircinia ramose and Psammocinia sp., respectively. This synthesis established the stereochemistry at C4 and C8, left unresolved at the time of isolation, and showed that Psymberin and Irciniastatin A are identical. Psymberin/Irciniastatin A is a very potent antitumor agent.