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Synfacts 2009(1): 0014-0014  
DOI: 10.1055/s-0028-1087231
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Eudistomin E

Contributor(s): Philip Kocienski, Zofia Komsta
H. Yamagishi, K. Matsumoto, K. Iwasaki, T. Miyazaki, S. Yokoshima, H. Tokuyama, T. Fukuyama*
University of Tokyo, Tokyo, Japan
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

Eudistomin E, extracted from a Caribbean tunicate Eudistoma olivaceum, showed some potent antimicrobial, antiviral and antitumor activities. The authors highlight a short route to the key indole moiety D starting from the nitro­arene A derived from the commercially available phenol, as well as a stereoselective Pictet-­Spengler reaction (F + G → H).