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Synfacts 2009(4): 0365-0365
DOI: 10.1055/s-0028-1088086
DOI: 10.1055/s-0028-1088086
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of ()-Dibromoagelaspongin
K. S. Feldman*, M. D. Fodor
The Pennsylvania State University, University Park, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. März 2009 (online)


Significance
Dibromoagelaspongin is an oroidin-derived guanidine alkaloid isolated from an Agelas sp. sponge and probably occurs in nature as a racemate. The structurally related phakellins have cytostatic activity. In this first total synthesis, the tetracyclic core is assembled by two consecutive Pummerer-type additions to a sulfur-substituted imidazole.