Synfacts

Category: Peptide Chemistry

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Issue 03/2025

Synthesis of β-Amino Acids from α-Amino Acids Using Visible-Light Photoredox Catalysis
Copper-Photoredox-Catalyzed Site-Selective Arylation and Alkylation of Glycine-Containing Peptides
TfOH-Mediated Late-Stage Functionalization of Tryptophan Peptide Residues
NHC-Catalyzed β-Keto Amino Acid Synthesis from Aldehydes and Imines
Copper-Catalyzed C(sp3)–H Benzylation at the α-Position of Glycine Derivatives
A New Coupling Reagent with No Heteroatomic Bonds for Amidation
Mn(OAc)3·2H2O-Mediated Phosphorylation of Dehydroamino Acids
A Liquid-Phase Peptide Synthesis (LPPS) Support for the Synthesis of Octreotide
Racemization-Free Visible-Light-Mediated Synthesis of Peptides
Synthesis of Unnatural Cyclic Peptides via Cu-Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides
Synthesis of Peptoids by a Flow Reaction Avoiding Undesired Diketopiperazine Formation
Accessing Photoswitchable Peptides by Embedding Spiropyrans in the Backbone of Peptides
A Facile Route to Accessing an Unusual Bicyclic Melanocortin-3 Receptor Antagonist: Compound 11
PTC-Catalyzed Asymmetric Alkylation of Glycine Imines for the Synthesis of Unnatural Amino Acid Esters
All PDFs of this category

Issue 02/2025

Palladium-Catalyzed Late-Stage Macrocyclization for the Synthesis of Cyclophane-Braced Glycopeptides
Photoredox-Catalyzed Glycosylation at Dha in Peptide Sequences
PIFA-Mediated Enantioselective Synthesis of Azatricycles
Stereoselective Synthesis of P-Stereogenic ProTides Catalyzed by a Copper Catalyst
Synthesis of Chiral α-Amino Acid Derivatives via Chiral Photocatalyzed Deracemization of NCAs
Synthesis of Cyclopropyl-Ring-Containing Unnatural Amino Acid Derivatives
β-Amino Acid Synthesis via Aminocarbonylation
Stereoselective Synthesis of Amino Esters via 1,5-Conjugate Addition Using Pd/Cu Dual Catalysis
Site-Selective C(sp3)–H Alkenylation of Peptides by Palladium(II) Catalysis
Synthesis of cis-4-Hydroxy-L-Prolyl Amides Using a Telescoped One-Pot Methodology
Self-Assembled Peptide with Installed Au(I) Complexes as Effective Catalysts for Intramolecular Cyclization
Synthesis of 1,2,4-Oxadiazoles Bearing Chiral N-Protected α-Amino Acids
All PDFs of this category

Issue 01/2025

Electrochemical Ring-Opening Reaction of Piperidine-Containing Peptides
Palladium-Catalyzed Late-Stage Functionalization for Installation of Maleimide Scaffolds into Peptides
Flavin-Catalyzed Synthesis of 4,5-Dihydroxynorvaline
BODNs as New Reagents for Visible-Light Photocatalytic Bromination of Tyrosine Residue
Synthesis of (2S,3R,4R)-Dihydroxyisoleucine (DHIle) and Its Application in Amatoxin Synthesis
Asymmetric Synthesis of β3-Tryptophan via C–H Amination
Pd-Catalyzed Synthesis of Thioglycopeptide
Synthesis of Diketopiperazines from α-Amino Amides and Diazophosphonate Ester Using Cp*Rh(III) Catalyst
Synthesis of Unnatural Amino Acids and Peptides via Desulfurative Alkylation of Cysteine Derivatives
Advanced Thiol Nucleophiles and Peptide Hydrazides in the Synthesis of Peptide Alkyl Thioesters
N-Terminal Thiazolidine-Containing Peptide Thioesters via a Thioproline-Based Oxidation Approach
1,2-Phospha-Brook Rearrangement for Synthesis of Phosphorylated Tyrosine Derived Peptides
Ethyl Propiolate Mediated Peptide Synthesis
All PDFs of this category

Issue 12/2024

Peptide Synthesis Using Unprotected Amino Acids
Late-Stage Functionalization for the Introduction of Sulfilimines into Peptides
Photoredox Catalysis for Site-Selective Aklylation of Glycine and Glycine-Containing Peptides
Iridium-Catalyzed Photoredox Functionalization of Glycine Derivatives
Enantioselective Synthesis of Unnatural α-Amino Acids Using Catalytic Addition of Thiol
Photochemical Strategy for Radical Pathway to Access β -Amino Acid Derivatives
Cyclic Tetrapeptide Synthesis via an Epimerization-Free Direct Aminolysis
Total Synthesis of Cyclic Hexapeptides: Nicrophorusamides A and B
Direct C–H Alkylation of Glycine Derivatives with Alkenes by Radical-Polar Crossover Reaction
Cyclization of N-Propargyl-N-Sulfonyl Amino Alcohols by Silver Catalysis and Solid-Phase Applications
Accessing Macrocyclic Thiolactone Peptides by Radical-Mediated Intramolecular Thiol–Ene Ligation
Asymmetric N-Allylation of Amino Acids and Peptides
Cobalt-Catalyzed Reductive Addition of Dehydroglycine
Alkylation of Glycine Derivatives via a Combination of Single-Electron and Halogen-Atom Transfers
Stereoselective Michael Addition Reaction for Synthesis of Unnatural Amino Acids
All PDFs of this category

Issue 11/2024

Electron-Rich Triaryl Phosphine Mediated Electrochemical Synthesis of Peptides
meso- and l,l-Diaminopimelic Acids: A Stereoselective Synthesis from α-Amino Acids
Cysteine-Directed Pd-Catalyzed β-C(sp3)–H Arylation of Alanine in Linear and Cyclic Peptides
Radical C–C Coupling Reaction for the Synthesis of CF3-Containing Amino Acids
Synthesis of α-Amino Acids via Iron-Catalyzed 1,3-Nitrogen Migration
Synthesis of Macrocyclic Peptides via Thioketalization of Cysteine-Containing Peptides
Hydroalkenylations of Olefins and Styrenes Using Iridium Catalyst via Enamine Formation
Synthesis of Aminonitriles by Asymmetric Strecker Reaction Using Organocatalysis
Catalytic Synthesis of Unnatural α/β-Amino Acids and  -Peptides
Methionine-Directed C–H Glycosylation of Peptides Catalyzed by Pd(OAc)2
Palladium-Catalyzed Cinnamylation and Decinnamylation of Complex Oligopeptides
Boronate Synthesis from Lys Derivatives
Sequential Fluorination and Amidation of Thioesters
FCDMT-Mediated Peptide Synthesis
All PDFs of this category

Issue 10/2024

Synthesis of Quaternary α-Amino Acids
Carbon-Isotope-Labeled Amino Acid Synthesis
Rhodium-Catalyzed Macrocyclization of Peptides
3,3-Difluoroallyl Sulfonium Salts Mediated the gem-Difluroallylation of Cysteine Residues in Peptides
Protection of Sterically Hindered Amide of Cyclo-(AA-Gly) Regioselectively Using Triisobutylaluminum
Aldolase-Catalyzed Enantioselective Amino Acid Synthesis from Glycine
Synthesis of 3-Benzyl-β-alanine Using Electrochemical Nickel-Catalyzed C(sp2)–C(sp3) Cross-Coupling
Enantioselective Synthesis of Unnatural Amino Acids by N–H Bond Insertion of Anilines
Epimerization-Free Native Chemical Ligation Using β-Lactone for the Synthesis of Polypeptides
α-Amino Acids by Reductive Carboxylation of Imines Using Formate and CO2
Pd-Catalyzed β-C(sp3)–H Olefination/Cyclization of Methionine-Containing Peptides
Direct Alkylamination of Tyrosine Derivatives Using Fe Catalysis and O-Benzoyl-N,N-dialkylhydroxylamines
Peptide Synthesis Using Unprotected Amino Acids with N-(Z-α-Aminoacyl)benzotriazoles
All PDFs of this category

Issue 09/2024

N-Methylated Peptide Synthesis Using Flow Chemistry
α,α-Disubstituted Unnatural Amino Acid Synthesis Using Photochemical Carboxylation
Chiral Phenanthroline-Potassium-Catalyzed Synthesis of Axially Chiral Biaryl δ-Amino Acid Derivatives
Utilizing Cyclen Installation as an Efficient Strategy for Macrocyclization and Multifunctionality of Peptides
Synthesis of Proline Derivatives via [1,2]-Stevens Rearrangement of Azetidinium Salts
Synthesis of Unprotected α-Tertiary Amino Acids Using Synergistic Photoenzymatic Catalysis
Macrocyclic Thiazol(in)e Peptide Synthesis from Peptide Nitriles Using a Biocompatible Strategy
Electrochemical Modification of Tryptophan and Tryptophan-Containing Peptides
Tertiary Amine Catalyzed Late-Stage Tryptophan Allylation of Peptides
Synthesis of Functionalized Diketopiperazines
Photocatalyzed Synthesis of Unnatural α-Amino Acids
Asymmetric Synthesis of α,α-Disubstituted α-Amino Acid Esters via Tsuji–Trost Allylation
O-Hydroxybenzenesulfonyl Chloride Mediated Peptide Synthesis
All PDFs of this category

Issue 08/2024

Peptide Cyclization at Side Chain of Lys-Lys, Lys-Tyr, and Lys-Phe(4-NH2)
Late-Stage Michael Addition to Form Phosphorus-Containing Peptides
Visible-Light-Mediated Synthesis of Unnatural Amino Acid and Peptide Derivatives
Amino Acid Synthesis via Photobiocatalytic Asymmetric C(sp3)–C(sp3) Oxidative Cross-Coupling
Ru(II)-Catalyzed C–H Arylation of N-Aryl Triazoles and Tetrazoles with Phenylalanine-Derived Sulfonium Salts
Visible-Light-Mediated Peptide Macrocyclization via Intermolecular Interception of Desulfurization
Development of Deprotective Amidation Utilizing Nms-Amides
Development of Amidation via Decarboxylative Cross-Coupling of Carboxylic Acids and Isocyanides
Histidine-Directed β-C(sp3)–H Arylation of Alanine-Containing Peptides
Triphenylphosphine- and Iodine-Mediated Rapid Peptide Synthesis
Efficient Synthesis of Bicyclic Peptides via Chemoenzymatic Tandem Cyclization
Utilizing Cysteamine in Peptide Ligation
Practically Simple Method for the Synthesis of N-Formyl Amino Acid Esters
S-Alkylation of Cysteine-Containing Peptides
All PDFs of this category

Issue 07/2024

Utilizing Proline Surrogates in the Synthesis of ‘Difficult’ Peptides
Photoredox-Catalyzed C–H Decyanative Pyridination of N-Arylated Glycine Derivatives with Cyanopyridines
Photoredox-Catalyzed C–H Alkylation of N-Arylated Glycine Derivatives
Synergistic Pd/Cu Catalysis for the Synthesis of Unnatural Quaternary Amino Acids
Deoxyfluorinated Amidation of Carboxylic Acids Using Pyridinesulfonyl Fluoride
The Peptide Backbone-Targeted Installation of (4H)-Imidazolone cis-Amide Bioisosteres Synthetic Strategy
Deprotection of Fmoc Group Using Catalytic Amounts of DMAP under Solvent-Free Conditions
[2,3]-Sigmatropic Rearrangement for the Synthesis of Unnatural α,α-Disubstituted α-Amino Acid Derivatives
Dual Metal-Catalyzed Electrocatalytic Synthesis of Unnatural Amino Acids
AlCl3- and HFIP-Mediated Selective Deprotection of the N-Cbz Group
Ir-Catalyzed Synthesis of β-Substituted α-Amino Acids Using Alkene and Glycine Derivatives
Distal Amino Acids Formation by Amidation of Cyclic Ketones
Efficient Method for the Synthesis of N-Methylated Peptides
Synthesis of Amino Acids with Axially Chiral Diaryl Ethers Units
All PDFs of this category

Issue 06/2024

Synthesis of Peptides Inversely via the Utility of Transient Protected Amino Acids
5- and 6-Membered Heteroaromatics-Embedded Amino Acids Synthesis via Electrochemical Means
Visible-Light-Catalyzed Chemo-Selective β-C(sp3)–H Perfluoroarylation of Serine-Containing Peptides
Synthesis of Amino Acid Based Chiral Cyclic Carbonates
Near-IR-Induced Site-Selective Fluoroalkylation of Tryptophan and Tryptophan-Containing Peptides
Selective S- and N-Acylation of Glutathione Using N-Acyl Imidazole
gem-Difluorinated Cyclopropanes for α-Fluoro-allylation of Enantioselective Amino Acid Esters
Improved Synthesis of Sensitive Peptides via Fmoc Deprotection Approach
A Highly Diastereoselective Tandem Oxyhomologation–Coupling Method to Synthesize Amides and Peptides
Visible-Light-Mediated β-Amino Acid Synthesis from α-Amino Acids
gem-Difluoroallylation of Glycine and Glycine Residue in Peptides Using Organophotoredox Catalysis
Chemoselective Photocatalytic Desulfonylation of Tryptophan Based Peptides
CBMIT-Mediated Synthesis of Amino Esters and Peptides
All PDFs of this category

Issue 05/2024

Dehydrative Peptide Coupling Promoted by HBF4/MS 5Å
Synthesis of Functionalized Amino Acids from Cysteine Pentafluoropyridine
Chiral Ru-Li Combined Catalysts for Asymmetric Cyanation of α-Ketimino Ester Derivatives
Unprotected Cyclic Peptide Methylene Dithioacetals Synthesis by Rhodium Catalysis
Synthesis of α,α-Dialkyl Amino Acid Ethyl Esters Using Asymmetric Phase-Transfer Alkylation
Copper-Catalyzed C(sp3)–H Alkylation of Glycine Derivatives
Activation of N-Ts Amide C–N Bonds by N-Heterocyclic Carbene-Squaramide Bifunctional Catalyst
One-Pot Protocol to Access Spirocyclic Unnatural β-Amino Acids via C–H Activation/C–C Cleavage
Synthesis of β-Tertiary Amino Acids Analogues via Cobalt-Catalyzed Stereoselective Radical Addition
Copper-Catalyzed [3+2] Cycloaddition for the Site-Specific Modification of Peptides
Photoredox and Nickel-Catalyzed Glycosylation of Amino Acids and Peptides
Synthesis of Optically Active Amino Amides
Racemization-Free Synthesis of N-Formyl Amino Acid Esters
All PDFs of this category

Issue 04/2024

Quinoline-8-carboxamides Synthesis via Aldehyde C–H Bond Activation Using Palladium Catalyst
Organocatalytic Stereoselective Synthesis of β-Hydroxy-α-Amino Acids
Recyclable Bicyclic Benziodazolone-Mediated Peptide Coupling Reaction
B(C6F5)3-Catalyzed Diastereoselective Synthesis of Carbocyclic β-Amino Acid (CBAA) Derivatives
Mn-Catalyzed Visible-Light-Mediated Synthesis of Amide via Aminocarbonylation
Lewis Base-Catalyzed β-Amino Acids Synthesis from Trifluoro and Trichloro Acetamide and MBH Carbonates
Synthesis of Peptides via Nicotinate-Directed Transamidations by Zinc Catalysis
Synthesis of Chiral α-Vinylic Amino Acids via Enantioselective Aza-Nozaki–Hiyama–Kishi Reaction
α-Functionalization of Glycine to Access Functionalized Amino Acids and Peptides
Synthesis of Cross-Linked Pseudopeptides Using Pd-Catalyzed Carbonylative Coupling
Synthesis of Difluoroalanine (dfa) and Their Applications in Peptide Synthesis
Ru/Cu-Catalyzed Modification of Diphenyl Ketoimine Amino Acids and Peptides
Two Step Synthesis of β2,2-Amino Acids from Alkylidenemalononitriles and Cbz-Gly
Palladium-Catalyzed C(sp2)–H Activation for Site-Selective Functionalization of Peptides
CDMT-Mediated Peptide Synthesis
All PDFs of this category

Issue 03/2024

Peptide Cyclization of Unprotected Peptides with Cysteine at C-Terminal
Boronic Acid-Catalyzed Peptide Bond Formation from Serine- and Threonine-Derived Inert Esters
Metal-Free Synthesis of α‑Tertiary Amino Acid Derivatives via Photoinduced Cross-Coupling
Unnatural Peptide Synthesis through Rh(III)-Catalyzed Diastereoselective Ligation with Three Components
Isothiourea-Catalyzed Conjugate Addition to Form Proline Derivatives
Palladium-Catalyzed Photoinduced Alkylation for Glycine Derivatives
Direct Amidation of Unprotected Amino Acids Mediated by Hexylsilane
Co-Catalyzed Asymmetric Aza-Barbier Reaction: A Useful Method for α-Tertiary Amino Ester Synthesis
Direct Synthesis of γ-Amino Acid Derivatives via Cobalt-Catalyzed Aminoalkylative Carbonylation of Alkenes
Palladium-Catalyzed Cross-Coupling for the Synthesis of Pyridyl Amino Acids
All PDFs of this category

Issue 02/2024

Atom-Economical N-to-C Peptide Elongation
Three-Component Reaction of Diazoacetates, Sulfonamides, Imines to Form Unnatural Amino Acids
Regio-Selective Arylation Reaction for the Trp-Unit of Oligopeptides
Copper-Catalyzed Asymmetric Arylation to Synthesize β-Amino Ester Precursor
Electrochemical Arylation of Cysteine-Containing Peptides
Microwave-Assisted Transamidation of Boc-Activated Secondary Amides
Late-Stage C3Ar Functionalization of Tyrosine and Tyrosine-Containing Peptides with Maleimides
Nucleophilic Hydrazide-Catalyzed Chlorination of Tyrosine-Containing Peptides
Synthesis of α-Quaternary Amino Esters via Intramolecular Rearrangement
Synthesis of N-Aryl Amino Acid Esters
All PDFs of this category

Issue 01/2024

Electrochemical Pyridinyl Amino Acid Synthesis
Synthesis of Fluorinated Amino Acids Catalyzed by a Palladium/Copper/Lithium Ternary System
Late-Stage Modification of Oligopeptide Trp Units with Azoles
Rhodium-Catalyzed Asymmetric N-Alkylation for the Synthesis of α-Amino Acids
Direct Modification of Amino Acid Derivatives via Pd-Catalyzed δ-C(sp3)−H Thiolation
Site-Selective Metal Free C7–H Borylation of Tryptophan
Synergistic Photo-Redox Catalysis for Peptide Bond Formation
Cu-Catalyzed N–H Insertion of Tryptamines to Form Unnatural Amino Acids
Arndt–Eistert Reaction for the Synthesis of β-Amino Acids
All PDFs of this category

Issue 12/2023

Peptide Cleavage Reaction at the C-Terminal Arg Site
Amide Bond Formation Using Triflylpyridinium as Coupling Reagent
Thiol-Labile Amino Protecting Group that Suppresses the Epimerization in Peptide Synthesis
Enantio- and Diastereoselective Synthesis of β-Aminoamides Catalyzed by a Chiral NiH Complex
Fe-Catalyzed Alkylazidation of Alkenes for the Synthesis of α-Azido α-Amino Esters
Pd-Catalyzed Synthesis of (Z)-Trisubstituted Allylic Amino Acids
Esterification of Amino Acids by Using TCFH as Reagent
Benzylic Lithiation Reaction for the Synthesis of Unnatural Amino Acids
All PDFs of this category

Issue 11/2023

Cu-Catalyzed Regioselective Chlorination of Peptides
Asymmetric Synthesis of Polysubstituted Chiral Proline Esters from Azomethine Ylides and 1,3-Enynes
Photoinduced Pd-Catalyzed Synthesis of Chiral Piperidine 2-Carboxyamides
α-Benzylation of N-Aryl Amino Acids
Thiopeptide Synthesis Using Nitroalkanes
Asymmetric α-Allylation for the Synthesis of α,α-Disubstituted Amino Acids with Vicinal Chiral Centers
Catalytic Asymmetric α-Allylation of N-Unprotected Amino Esters
Metal-Free C2 Alkylation of Tryptophan and Tryptophan-Containing Peptides
Organocatalyzed Enantioselective Synthesis of α-Amino Acids
All PDFs of this category

Issue 10/2023

Rh-Catalyzed Maleimidation of Trp-Including Peptides
One-Pot Enantioselective Synthesis of α‑Amino Acid Esters
Synthesis of Small Cyclic Peptides Containing N-Methyl and β-Amino Acids
Asymmetric Synthesis of α-Sulfinamido Trithioformates and Transformation to Peptides
Co-Catalyzed Enantioselective Hydrogenation to Form Indazole-Containing Amino Acids
Palladium-Catalyzed Late-Stage Functionalization of Phenylalanine and Phenylalanine Derived Peptides
Cu-Catalyzed Three-Component Coupling for the Synthesis of α-Aryl α-Amino Acid Derivatives
Macrocyclization of Oligopeptides via Introduction of a Hypervalent Iodine Reagent
Direct Catalytic Asymmetric Synthesis of α-Alkylated α,α-Disubstituted Amino Esters
Photocatalyzed C–H Functionalization of Trp-Including Peptides
Ring-Opening of Aziridine Carboxylates for the Synthesis of Tryptophan Derivatives
All PDFs of this category

Issue 09/2023

Peptide Elongation Using α-NCAs Both as Nucleophiles and Electrophiles
Cu-Catalyzed Late-Stage Functionalization of Glycine Derivatives and Glycine-Containing Peptides
Silver-Catalyzed Intermolecular [3+2] Cycloaddition for the Synthesis of Tetrazole-Fused Amino Acids
Pinnick Oxidation to Form 4-Substituted Proline
Amine Installation and Facilitated Peptide Elongation
Ir-Catalyzed Functionalization of Cysteine-Containing Peptides
Peptide Modification Using Ag-Catalyzed C–H Amination
Fluorous Sulfur-Containing Boronic Acid Catalyst for Amidation
Synthesis of Sterically Hindered Tripeptides Using a Modified Ugi Reaction
Cu-Catalyzed γ-Addition to Form Unnatural Amino Acid Bearing Allene Units
All PDFs of this category

Issue 08/2023

Efficient Method for Cyclic Peptide Synthesis Mediated by Acylammonium Species
Ir-Catalyzed Functionalization of Alkyl Silane with Benzosultam
Organocatalyzed Synthesis of Cyclized Amino Acids with Cyanocoumarin
Copper-Catalyzed Synthesis of α,α-Disubstituted Amino Acid Derivatives
Enantio- and Diastereoselective Annulation to Form Fused Amino Acid Derivatives
Synthesis of anti-β-Amino Organoborons via Radical Hydroboration
AlMe3-Mediated One-Pot Peptide Bond Formation of N- and C-Terminal Amino Acids
Diboronic Acid Anhydride-Catalyzed Synthesis of Serine or Threonine Containing 2,5-Diketopiperazines
Synthesis of Unnatural Amino Acids from in situ Generated Glycine Cation Equivalents
W-Catalyzed C(sp3)–H Alkylation of Valine
All PDFs of this category

Issue 07/2023

C–H Functionalization for the Synthesis of Maleimide-Decorated Peptides and Macrocyclic Peptides
Regioselective Fluorination of Amino Acid Derivatives
Electrosynthesis of γ,δ-Unsaturated α-Amino Esters
Pd-Catalyzed α-Allylation of N-Unprotected Amino Acids
One-Pot Synthesis of Amnio Acids with Consecutive Tetrasubstituted Stereogenic Center
Asymmetric Alkylation to Afford Tetrasubstituted Amino Acids
Copper-Catalyzed Synthesis of α-Amino Acids from Primary Alcohols
Selective Deprotection of tert-Butyl Ester Groups in N-Boc-Protected Amino Acid tert-Butyl Esters
All PDFs of this category

Issue 06/2023

Fe-Catalyzed Alkylation of Glycine Derivatives
Synthesis of β-Aminocyclobutanecarboxylic Acid Derivatives
Synthesis of Unnatural Peptides by Deaminative Reductive Cross-Coupling Reactions
Electrochemical N-Methyl β-Amino Acids Synthesis
Co-Catalyzed Dideuterated α-Amino Aicd Synthesis
Electrochemical Synthesis for Phosphorylated Amino Acid Derivatives
Development of Mild Conditions for the Deprotection of the tert-Butoxycarbonyl Protecting Group
Synthesis of Amino Acid Derivatives via Free Carbene Insertion
All PDFs of this category

Issue 05/2023

Ir-Catalyzed Enantio- and Diastereoselective Synthesis of 3-Substituted Proline Derivatives
Iodide-Mediated Amidation Reaction under Electrochemical Conditions
Photochemical Synthesis of Unnatural Amino Acids through CF3 Radical Addition to Michael Acceptors
Synthesis of Quaternary-Substituted α-Amino γ‑Butyrolactams
Pd and Cu Synergistic Catalysis for the Synthesis of α,α-Disubstituted Amino Acids
Synthesis of Fluorinated Non-Canonical Peptides from α-Fluorinated Carboxylic Acid
β,γ,δ,ε-Amino Acid Synthesis by Photocatalytic Carboxylation with CO2
Arylation of Short Peptides Using a Palladium Catalyst
Deprotection of 2,2-Dimethyl-2-(o-nitrophenyl)acetyl (DMNA) Group in Amino Acids and Peptides
All PDFs of this category

Issue 04/2023

Rh(III)-Catalyzed Synthesis of Unnatural Peptides
Coupling of Amino Acid Terminal Alkyne with in situ Iminium Ion to Access Nε‑Substituted Lysine Mimetics
Visible-Light-Mediated Continuous-Flow Technology for the Synthesis of α-(N-Hydroxy)amino Amides
Modification of Diamino Acid-Containing Hydrospirophosphoranes
Acetoxylation of Tyrosine-Containing Peptides Using a Palladium Catalyst
Palladium-Catalyzed C–H Alkenylation to Form Maleimide-Braced Peptides
Organocatalyzed Enantioselective N–H Insertion
Synthesis of N-Formyl Amino Acid Esters
All PDFs of this category

Issue 03/2023

Cu-Catalyzed Introduction of Oxime Ethers into Peptides
Rh/Chiral Phosphoric Acid Cocatalyzed Synthesis of N-(Anthrancen-9-ylmethyl) Isoserines
Squaramide-Catalyzed Amino Acid Induced Tetrahydro-β-Carboline Synthesis
Visible-Light Photocatalysis for the Synthesis of Quaternary Alkynyl α‑Amino Esters
Photoinduced Coupling Reaction of Glycine Derivatives with N-Alkoxyphthalimides
Synthesis of Unnatural Amino Acids from Glycinates
Cu-Catalyzed Borylamination for the Synthesis β-Boryl-α-amino Esters
Chiral Aldehyde-Ni Dual-Catalyzed α-Propargylation to α-Amino Acids
One-Pot Synthesis of N-Methyl Dipeptides from Amino Acid-Derived Oxazolidinones
All PDFs of this category

Issue 02/2023

Late-Stage Functionalization for the Construction ­of Proline Skeleton in Peptides
N-Indole-Protected Peptide Synthesis
Pd-Catalyzed Deuteration of Amino Acids
Cu-Catalyzed Hydrogermylation of Dehydro Amino Acids
Three-Component Coupling to Afford α,α-Diaryl Amino Acids
α-Amino Acid Amidation Using a Silicon Reagent
Indolylation of N-2-Nitrophenylsulfenyl Imino Peptides
C–H Functionalization at the β-Position of Dehydroamino Acids
Chemoselective Cleavage of the tert-Butoxycarbonyl Group from Di-tert-butylimidodicarbonate
All PDFs of this category

Issue 01/2023

Ynamide-Mediated Peptide Synthesis
Transfer Hydrogenation of α-Aryl Imino Esters for the Synthesis of α-Amino Acid Esters
Cu-Catalyzed N–H Insertion of α-Alkyl-α-Diazo-acetates to Form N-Protected α-Alkyl Amino Esters
Rh-Catalyzed Polyfluoroaryl Amino Acids Synthesis
Synthesis of Glycopeptides Linked by Disulfide
Rh-Catalyzed Three-Component Coupling Reaction to Form α,β-Tetrasubstituted Amino Acids
Enantioselective Synthesis of α-Amino Acid Derivatives
MgO-Mediated Synthesis of Fmoc-Protected Amino Acid Hydroxamates
All PDFs of this category

Issue 12/2022

Domino Reaction to Form Polycyclic Spiro Compounds Containing Amino Acid Residues
Nickel/Iridium-Catalyzed Cross-Coupling of Amino Acid Chlorides with C(sp3)–H Hydrocarbons
Photoredox Cobaloxime/Iridium Complex-Catalyzed Peptide-Bond Formation
Microwave-Induced Inverse Peptide Synthesis
Copper-Catalyzed Alkynylation of Azapeptides
Zinc-Catalyzed Desymmetric Reduction To Form Hydroxylated Tetrasubstituted Amino Acids
Electrochemical Tandem Azidation/Heterocyclization of Tryptophan-Containing Peptides
Synthesis of N-Allyl Amino Acids and Peptides
All PDFs of this category

Issue 11/2022

Palladium-Catalyzed C(sp3)–H Arylation of Cyclic Peptides
C–H Alkylation for the Synthesis of Tetrasubstituted Amino Acid Derivatives
Primary Amine–Thiourea-Catalyzed Enantioselective Alkylation of Cyclic Ketones
Functionalization of Aspartic or Glutamic Acids through Photoinduced Decarboxylation
Iridium-Catalyzed Photochemical [2+2]-Cycloaddition of Dehydroamino Acids with Styrenes
Synthesis of α-Amino Acids by Enantioselective Carbene Insertion
Potassium Fluoride-Mediated Deprotection of Fmoc-Amino Acid Esters: One-Pot Peptide Synthesis
Chiral Calcium Phosphate-Catalyzed Amination of β-Keto Esters
All PDFs of this category

Issue 10/2022

Preparation of Dehydroamino Acids/Peptides and their Application
Palladium-Catalyzed Cyanomethylation of Amino Acids
Photoredox C(sp3)–H Bond Activation to Form Tetrasubstituted Amino Acids
Copper/Iridium-Catalyzed Cascade Reaction for the Synthesis of α-Deuterated α-Amino Acids
Asymmetric Mannich Reaction for the Synthesis of β-Amino Amides
Microwave-Assisted Aminocarbonylation of α-Amino Acid Esters
α,β-Diamino Acid Synthesis by a Mannich-Type Reaction of Azlactones and 2-Aminoacrylates
Iridium-Catalyzed Carbonyl Alkylative Amination Reaction under Blue LED Irradiation
(Diethylamino)sulfur Trifluoride (DAST) for Fmoc-Amino Acyl Fluoride Synthesis
All PDFs of this category

Issue 09/2022

Synthesis of Peptides with the Formation of Highly Sterically Hindered Peptide Bonds
Aza-Quasi-Favorskii Reaction Mediated by Potassium Hexamethyldisilazide
Visible Light-Induced Cross-Coupling of Glycine Derivatives with β-Keto Esters
Palladium-Catalyzed Aminoallylation for the Synthesis of α,α-Disubstituted Amino Acids
Ruthenium-Catalyzed Hydroxylation of Tyrosine Residues in Peptides
Asymmetric Synthesis of Quaternary Amino Acid Esters
Rhodium-Catalyzed Ligation of Peptides with Olefins
Synthesis of α-Benzyl Amino Acid Derivatives by Using a Ternary Catalyst
1H-Fluoren-9-ylmethyl Chloroformate as a Coupling Reagent for Peptide Synthesis
All PDFs of this category

Issue 08/2022

Palladium/Copper-Catalyzed Synthesis of α-Alkenyl α-Amino Acids from 2-Fluoro-1,3-dienes
Synthesis of Peptide α-Keto Acids and Application to Decarboxylative Peptide Coupling
Ruthenium-Catalyzed Late-Stage C–H Acyloxylation of Peptides
Dual-Protein-Catalyzed Site-Selective Deuteration
Peptide Bond Formation Mediated by Thionyl Fluoride
Electrocarbonylation of N-Acylimines with Atmospheric Carbon Dioxide
Post-Translational Modifications of Dehydroalanine: Synthesis of Asparagine Derivatives
Iridium-Catalyzed Asymmetric N-Allylation of Amino Acids
Synthesis of Optically Active β- or γ-Amino Acid Derivatives
Expeditious Deprotection of N-Benzyloxycarbonyl and N-Benzyl Derivatives
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Issue 07/2022

1,2-Diaminotruxinic Bis-amino Acid Synthesis
Site-Selective Replacement of N-Protecting Groups in Peptides
A Novel Reagent for Coupling of Amino Acid Chlorides with Amino Acid Esters
Lewis Acid/Palladium-Catalyzed Synthesis of α-Amino Acid Derivatives
Synthesis of Carborane-Decorated Tryptophan-Containing Peptides
Nickel/Copper-Catalyzed Synthesis of Tetrasubstituted Amino Acids
Copper-Catalyzed Cross-Dehydrogenative Coupling for Amino Acid and Peptide Synthesis
Synthesis of Functionalized and Macrocyclic Peptides by C–H Olefination
α-Trifluoromethyl Amino Acid Synthesis by a Biocatalytic N–H Carbene Insertion
All PDFs of this category

Issue 06/2022

Dipeptide Synthesis by Two-Component Organocatalysis
Site-Selective Alkylation for the Synthesis of Azapeptides
Urethane-Protected Amino Acid N-Carboxyanhydride Synthesis in a Microflow System
Nickel-Catalyzed Enantioselective Synthesis of Unnatural Amino Acids
C–H Azidation of Peptides and Applications of the Products
Arene Triazene Reaction for Macrocyclization of Unprotected Peptides
Ruthenium-Catalyzed Synthesis of Unnatural Amino Acids through Transfer Hydrogenation of Enamides
Iridium-Catalyzed N-Alkylation of α-Amino Esters and Amides
Synthesis of Versatile N-Protected Amino Acid Esters from Aryl 4-Nitrosulfonates
Construction of N,O-Acetals of Unnatural Amino Acids from Diethyl Mesoxalate Derivatives
All PDFs of this category

Issue 05/2022

Cyclopeptide Synthesis by Ring-Closing Metathesis
Iridium-Catalyzed Synthesis of α-Amino Esters by α-Amidation
Synthesis of Fluorine-Containing Amino Acids from Sulfamidates and Potassium Fluoride
Diastereoselective Allylation of α-Imino Esters for the Synthesis of Sterically Hindered Amino Ester and Peptides
Copper-Catalyzed Silylamination for the Synthesis of β-Silyl-α-amino Acids
Enantioselective Synthesis of Unnatural Amino Acids Catalyzed by a Chiral Phosphoric Acid
Double Mannich Alkylamination to Form Benzofuran-Fused Amino Acid Derivatives
Trimethoxy(methyl)silane-Mediated Amidation of Carboxylic Acids
Design and Synthesis of a Thiazolium-Based Coupling Reagent for Peptide Synthesis
All PDFs of this category

Issue 04/2022

Photocatalytic Synthesis of Amino Acid Amides
Cinchona Alkaloid-Catalyzed α-Selenylation of Amino Acid Derivatives
5-Nitro-4,6-dithiocyanatopyrimidine: A Novel Coupling Reagent for Peptide Synthesis
Palladium-Catalyzed Site-Selective Modification
Synthesis of Peptide Thioesters via Ynamides
Nickel-Catalyzed C(sp3)–C(sp3) Cross-Coupling for the Synthesis of Unnatural Amino Acids
Copper-Catalyzed Asymmetric Conjugated Addition to Form Chiral α-Amino Acids
Ru- or Rh-Catalyzed C–H Functionalization of Amino Acid-Derived Phosphinamides with Alkynes
Peptide Modification by Bicyclobutane–Triazolinedione Cycloadditions
Cobalt-Catalyzed Oxidative Functionalization of Cyclic Ethers to Form Fluorinated Amino Acids
Copper-Catalyzed β-Alkylation of Amino Acid Schiff Bases
Solid-Phase Synthesis of α-Amino Alkyl or Aryl Phosphonopeptide Derivatives
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Issue 03/2022

Thionyl Fluoride-Mediated Peptide Synthesis
Peptide Bond Formation with Ynamide Coupling Reagents
Synthesis of Unnatural α-Amino Acids Mediated by Visible Light
Palladium-Catalyzed Thiazole-Directed C(sp3)–H Arylation of Peptides
Iridium-Catalyzed C–H Amination of Benzoic Acids
Synthesis of β3-Amino Acid Derivatives by Using an Imidodiphosphorimidate Catalyst
Palladium-Catalyzed Decarbonylation of Amino Acid Derivatives with an Aminoquinoline Directing Group
Silver-Catalyzed Enantioselective Synthesis of Pyroglutamic Acid Esters
A Silyl Carbamate Linker for Solid-State Peptide Synthesis in the Reverse Direction
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Issue 02/2022

Electrochemical Synthesis of Peptides Mediated by Triphenylphosphine
Visible Light-Driven C–H Ketoalkylation of Glycine Derivatives with Cycloalkyl Peroxides
Synthesis of Pyrazole-Based α-Amino Acids by Chiral Phosphoric Acid Catalysis
Copper-Catalyzed Electrophilic Amination of Substituted Isoxazolidin-5-ones to Form β-Amino Acids
Dynamic Kinetic Resolution to Access α-Amino Acid Esters
Synthesis of Dehydroalanine Derivatives from Diamino Diacids by a Radical Process
Synthesis of Na-Fmoc-Protected Amino Acid Esters and Peptides
Copper-Catalyzed Synthesis of Thioamide Peptides
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Issue 01/2022

Photochemical Functionalization of Peptides on a Solid Support
C–H Activation/Lossen Rearrangement/Annulation to Access Trifluoromethylated Amino Acids
Palladium-Catalyzed Multiple S-Arylation for the Synthesis of Macrocyclic Peptides
Nickel-Catalyzed Alkenylation and Arylation of α-C-Tosyl Peptides with C(sp2) Triflates/Halides
Electrochemical Synthesis of Amino Acid Amides Catalyzed by TEMPO
Palladium-Catalyzed Olefination of Tryptophan Residues in Peptides
Organocatalytic Synthesis of Chiral α-Halo-α-Aryl-β2,2-Amino Acid Derivatives
Molybdenum-Catalyzed Indane-Based Amino Acid/Peptide Synthesis
Electrochemical Synthesis of N-Boc-α-Amino Acids
Racemization-Free Dipeptide Synthesis by Using a Chloro(triphenyl)phosphonium Intermediate
N-Propyl-1H-pyrazole-1-carboximidamide for the Synthesis of Nω-Propylarginine-Containing Dipeptides
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Issue 12/2021

Peptide Synthesis by Asymmetric Transamination of α-Keto Amides
Nickel-Catalyzed Cross-Coupling of α-Amino-β-bromocarboxylic Acid Esters with Aryl Bromides
One-Pot Approach for Diastereoselective β-Lactam Synthesis
Photoredox-Catalyzed Amidation of Amino Acids or Peptides with Nitroarenes
Palladium-Catalyzed C–H Acylation of Tyrosine-Containing Peptides
Photocatalytic Carbamoylation of Azomethine Imines
Cyclization of ω-Amino Fatty Acids by Reductive Amination of Carbonyl Derivatives
Decarboxylative Propargylic Alkylation: Synthesis of Tetrasubstituted α-Amino Acid Esters
Propargyl Pentafluorophenyl Carbonate as a Coupling Reagent for Peptide Synthesis
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Issue 11/2021

Rhodium-Catalyzed α-Tetrasubstituted α-Amino Acid Synthesis
Selenium Solid Support for the Synthesis of AM-Toxin II
Allenone-Mediated Formation of Peptide Bonds
N-Arylation of Imidazole Side Chain of Histidine or Histidine-Containing Peptides
Selective Modification of Peptides through Cleavage of a Secondary Amide Bond
Radical-Coupling Reaction for the Synthesis of γ-Amino Acid Esters
Visible Light-Mediated C–H Amination of Amino Acids or Peptides
Chiral Pyridoxal-Catalyzed Synthesis of β-(Trifluoromethyl)-β-hydroxy-α-amino Acid Derivatives
Visible Light-Mediated Selenium–Sulfur Bond Formation to Afford Selenium–Sulfur Bond-Containing Peptides
Copper-Catalyzed Synthesis of α-Amino Acid Derivatives by C(sp3)–H Alkylation
Nickel-Catalyzed Glycosylation of Amino Acids or Peptides
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Issue 10/2021

Organoboron-Catalyzed Synthesis of Serine- and Threonine-Derived Weinreb Amides
Palladium-Catalyzed C–H Functionalization of Cyclic-Aminal-Protected Peptides
Synthesis of Sulfonyl Fluoro Peptides by an Ugi Reaction
Unnatural Peptide Synthesis by Photochemical Acyl Radical Addition of Dehydroalanine
Palladium-Catalyzed Modification of Aspartic Acid-Containing Peptides
Electrochemical Synthesis of α-Amino Esters
Enantioselective Synthesis of 2-Chloroaziridines
Chiral Phosphoric Acid-Catalyzed Synthesis of α-Amino Esters
Ruthenium-Catalyzed Dehydrogenative Amidation of Alcohols by Amines
Unnatural α-Amino Acid Synthesis by Photoinduced Alkylation of Dehydroalanine
Synthesis of a Side-Chain-Tethered Solid Support for Peptide Synthesis
Synthesis of γ-Oxo-α-Amino Acids by Iridium Catalysis
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Issue 09/2021

Solar Radiation-Assisted Peptide-Bond Formation
C(sp3)–H Functionalization for Modification of Peptides with Alanine at the C-Terminus
Nickel-Catalyzed Synthesis of α-Amino Acid Derivatives
Photocatalytic Phosphotyrosine Mimetic Functionalization of Peptides
Enantioselective Synthesis of α-Amino Acid Esters by Rhodium/Copper Catalysis
Photoredox Amidation of Tryptophan in Peptides
Late-Stage Palladium-Mediated N-Arylation of p-Aminophenylalanine in Unprotected Peptides
Hybrid Peptide Synthesis by Radical–Radical Coupling
Trimethylaluminum-Mediated Peptide Synthesis
Palladium(II)-Catalyzed C(sp2)–H Functionalization of Tryptophan and Tryptophan-Containing Peptides
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Issue 08/2021

Synthesis of Azobenzene-Functionalized Peptides by Modification of Tyrosine-Containing Peptides
Synthesis of 1,3-Benzoxazepines and their Conversion into o-Tyrosine Analogues
Site-Selective C–H Functionalization of Tryptophan Derivatives
Organocatalytic Mannich Reaction for the Synthesis of β-Amino Acid Esters
Copper-Catalyzed Synthesis of Cyclic β-Amino Acids from Isoxazolidin-5-one Derivatives
Palladium-Catalyzed Glycosylation of Arginine
Potassium-Catalyzed Asymmetric Mannich Reaction
Copper-Catalyzed Difluoromethylation of Amino Acids to Induce a New Tetrasubstituted Carbon Stereocenter
Copper-Squaramide-Catalyzed Synthesis of α-Amino Acid Derivatives
One-Pot Protocol for Peptide Synthesis from Unprotected or Partially Protected Amino Acids
Zinc Dust Mediated Peptide Synthesis from Fmoc-Amino Acid Chlorides and Amino Acid Hydrochlorides
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Issue 07/2021

Palladium-Catalyzed Olefination of Oxazole-Containing Peptides
Oxidative Peptide Bond Formation of 2-(Aminomethyl)malononitriles
Copper-Catalyzed Synthesis of Bulky Amides and Peptides
Hypervalent-Iodine-Mediated Peptide-Bond Formation to Synthesize Hindered Peptides
Nickel-Catalyzed Synthesis of β-Amino Acid Derivatives
Synthesis of Isoquinolone-Containing Amino Acids by Rhodium-Catalyzed C–H Annulation
Palladium-Catalyzed δ-C(sp3)–H Arylation of Amino Acids
Petasis Reaction for the Synthesis of Unnatural Amino Acids
Synthesis of N-Unprotected α-Amino Acid Methyl Esters
Photoredox-Catalyzed Synthesis of γ-Amino Acid Derivatives
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Issue 06/2021

Manganese-Catalyzed Late-Stage Functionalization of Peptides
Iodine-Catalyzed Oxidative 2-Selenylation of Tryptophans
Synthesis of β2-Amino Acid Derivatives by Aminomethylation of Arylacetic Acid Esters
Tetrabutylammonium Decatungstate-Catalyzed Synthesis of γ-Carbonyl α-Amino Acids
Photoredox-Catalyzed Radical Addition to Glyoxylate-Derived N-Sulfinyl Imines
Phospha-Michael Addition to Access β-Phosphorus-Containing α-Amino Acids
Phosphate-Reagent-Mediated Peptide Coupling Reactions
N-Arylation of Amino Acids without Using Transition Metal Catalysts
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Issue 05/2021

Catalytic Intramolecular C–H Alkylation for the Synthesis of Peptide Macrocycles
Phase-Transfer-Catalyzed Synthesis of 4-Cyanotryptophan
Palladium-Catalyzed Intramolecular Peptide Macrocyclization
Synthesis of α-Sulfanyl-β-Amino Acids by a Mannich-Type Reaction
[3+2] Photocycloaddition of a Cyclopropylurea with α-Substituted Acrylates
Visible-Light Photoredox-Catalyzed Redox-Neutral Carbocarboxylation of Activated Alkenes
Organophotoredox and Hydrogen Atom Transfer Catalysis for the Synthesis of β-Silyl α-Amino Acids
Palladium/Copper Catalysis to Access α-Amino Esters
Thiopyridone-Derived Reagents for Peptide Coupling Reactions
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Issue 04/2021

Ball-Milling Strategy for Epimerization-Free Peptide Synthesis
Rhodium-Catalyzed Synthesis of β2/γ2/δ2-Amino Acid Derivatives
Synthesis of All-Alkyl α-Tertiary Amino Acid Derivatives under Visible-Light Irradiation
β-Seleno-α-Amino Acids Synthesis by Seleno-Michael Additions to Bicyclic Dehydroalanine
Photocatalyzed Modification for Tryptophane-Containing Peptides
Triflic Acid Catalyzed N–H Insertion Reaction for the Synthesis Unnatural α-Amino Esters
Synergistic Brønsted Acid/Photoredox Catalysis for the Synthesis of α-Amino Acids
Rhodium-Catalyzed Formation of Proline Analogues
Peptide Bond Formation by Using 2-Pyridyl Thio Esters
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Issue 03/2021

Fluorine-Containing Azaheterocyclic β-Amino Acids
Brønsted-Acid-Catalyzed Enantioselective Aza-Friedel–Crafts Reaction
Rhodium-Catalyzed Formation of Disulfide Bonds in Water
Synthesis of Cyclic Peptides by Cooperative Stapling of Native Peptides at Lysine and Tyrosine or Arginine
Synthesis of Tetrasubstituted α-Amino Acids by an Ireland–Claisen Rearrangement
Silver-Promoted Synthesis of Cyclic Peptides by Ring Expansion
Chlorophyll-Catalyzed 1,2-Acyl Migration of Enaminones To Give Quaternary α-Amino Esters
Boron-Containing Aza-Amino Acids
Nickel-Catalyzed Hydroamination of Alkenes
Radical Substitution Reaction for the Synthesis of Nonnatural Amino Acid and Peptides
Late-Stage Site-Selective Rhodium-Catalyzed C(7)-Amidation of Tryptophan Residues
Peptides Synthesis by Using Nitrophenyl Esters
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Issue 02/2021

α-Amino Acid Synthesis from Azlactones Catalyzed by a Chiral 2-Substituted Pyridine N-Oxide
Palladium-Catalyzed γ-C(sp3)–H Arylation of Peptides
Cysteine-Catalyzed Peptide Synthesis in Neutral Water
Amidation of Carboxylic Acids with Amine–Borane Complexes
Nickel-Catalyzed Reductive Coupling Reaction of α-Pivaloyloxyglycine
Asymmetric 1,3-Dipolar Cycloaddition Reaction for the Synthesis of Polysubstituted Prolines
Dipeptides Synthesis by Using Phosphazene Bases to Enhance the Solubility of Amino Acids
Rhenium-Catalyzed C–H Activation for the Synthesis of β-Trifluoromethyl β-Amino Esters
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Issue 01/2021

Anhydride-Mediated Peptide Synthesis with C-Terminal Unprotected N-Methylamino Acids
Rhodium-Catalyzed C–H Olefination of Tryptophan Residues
Palladium-Catalyzed Acylation of Tyrosine-Containing Peptides
γ-Amino Acids Synthesis from meso-Glutaric Anhydrides Mediated by Polystyrene-Bound Hünig’s Base
Hydroxy-Directed Diboronic Acid Anhydride-Catalyzed Peptide Synthesis
Azetidine-Based Stereoselective Amino Acid Synthesis
Nickel-Catalyzed Four-Component Coupling Reaction
β2,2-Amino Acid Synthesis from Ketenes and N,O-Acetals
Peptide Bond Formation by Using p-Nitrophenyl Esters
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Issue 12/2020

Visible-Light-Mediated Functionalization of Cysteine Derivatives and Cysteine-Containing Peptides
Synthesis of Hexahydropyrrolo[3,4-b]pyrrole-Fused Quinolines from α-Amino Acid Methyl Esters
Iridium-Catalyzed Synthesis of Quaternary α- through ε-Amino Acid Derivatives
Palladium-Catalyzed Synthesis of Azatryptophan Analogues
Copper-Catalyzed Synthesis of Peptide-Containing Macrocyclic Alkynyl Sulfides
Photoredox-Catalyzed Synthesis of γ-Amino Acids from Styrenes, Amines, and CO2
Three-Component Reaction Toward γ-Carbonyl-α-Amino Acids
Modification of the N-Terminus of Peptides
Synthesis of Reactive Amino Acid Esters by Using Amino Acid Chlorides in a Biphasic System
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Issue 11/2020

Palladium-Catalyzed C(sp3)–H Arylation of Peptides Assisted by Unmodified Asparagine
Ni-Catalyzed Decarboxylative Borylation toward α-Aminoboronates and Peptide-Boronic Acids
Synthesis of Peptides Containing α,α-Difluoro-β-amino Acids from α,α-Difluoro Lactams
Transamination for Synthesis of Unprotected Glycine Derivatives
Modification of Tryptophan by Using Triarylbismuthines and Copper(II) Acetate
Photoredox-Catalyzed Synthesis of α-Amino Acid Derivatives
Chiral Phosphoric Acid-Catalyzed Synthesis of α-Amino Acid Derivatives
Cooperative Catalysis for the Synthesis of β-Prolines
Synthesis of Cyclic Peptides by Palladium-Catalyzed Intramolecular C(sp3)–H Arylation
Photoinduced α-C(sp3)–H Functionalization of Amino Acids and Peptides
Dipeptide Synthesis from S-2-Formyl-4-Nitrophenyl Thioesters and Amino Acid Salts
Decarboxylative Carbonylation of α-Amino Acids
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Issue 10/2020

Coupling of Amino Acids and α-Branched Aldehydes
Vicinal Tetrasubstituted Oxindole-Derived Acyclic Amino Acid Synthesis by a Mannich-Type Reaction
One-Pot Synthesis of β-Amino Secondary Amides from Vinylic Azides and N-Acyl Imines
Efficient Method for Peptide Synthesis in Water by Using Amphiphile PS-750-M
Metallaphotoredox-Catalyzed Synthesis of γ-Amino Acid Derivatives
[3+2]-Cycloaddition Reaction for the Synthesis of Spirocyclic α-Amino Esters
Cu-Catalyzed Ligand-Controlled Synthesis of β-Amino Acid Derivatives
Synthesis of Fluorinated Quaternary α-Amino Acid Esters
Photoredox Decarboxylative Coupling for α-Amino Acids Synthesis
Copper-Catalyzed C(sp3)–H Bond Activation to Access α-Alkoxylated Amino Amide Derivatives
Synthesis of Reactive Amino Acid Esters by Using 9-Fluorenylmethyl Chloroformate
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Issue 09/2020

An N-Protecting Group for Solid-Phase Peptide Synthesis in Aqueous Media
Enantioselective Synthesis of Proline Derived Bicyclics
Palladium-Catalyzed Peptide Macrocyclization
Copper-Catalyzed 1,3-Dipolar Cycloaddition of Glycine Imino Esters
Alkylation of Glycine Derivatives to Access Nonnatural Amino Acids
Decarboxylative Synthesis of α-Amino Acids from Malonates
Ni/Cu-Catalyzed Synthesis of α-Quaternary Amino Acid Derivatives
Stereodivergent Synthesis of Serine and Cysteine Derivatives by Copper/Iridium Catalysis
Palladium-Catalyzed γ-C(sp3)–H Bond Arylation of Amino Esters
Palladium-Catalyzed C–H Bond Vinylation of Amino Acids and Peptides
A Novel Reagent for tert-Butoxycarbonylation of Amino Acids
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Issue 08/2020

Copper-Catalyzed Synthesis of Nonnatural α-Amino Acids
Synthesis of Fluorodehydroalanine-Containing Peptides
Rhodium-Catalyzed Synthesis of α-Amino Acid Derivatives
Nickel-Catalyzed Hydrogenation to Form α-Amino Acid Derivatives
Palladium-Catalyzed Synthesis of α-Amino Acid Derivatives from Hydrazones and Boronic Acids
Deracemization Strategy for the Synthesis of Nonnatural Amino Acid Derivatives
Catalytic Two-Step Synthesis of Azetidine 3-Aryl-3-Carboxylic Acids
Iron-Catalyzed Synthesis of α,α-Disubstituted Amino Acids from Azlactones and Indoles
Synthesis of Allylic Amino Acid Derivatives by a Palladium-Catalyzed Cross-Coupling Reaction
Synthesis of β2-Amino Acids from β-Phthalimido-α-xanthylpropionic Acids by Radical Addition
All PDFs of this category

Issue 07/2020

Synthesis of Peptides with Acyl N-Methylimidazolium Cations
Photocatalytic Conjugate Addition of Amino Acids or Peptides
Chiral Nonnatural α-Amino Acid Synthesis by Enantio-selective Mannich Reaction and Hydrogenation
Base-Controlled Synthesis of α- and β-Amino Acid Derivatives from Azirine Rings and Arylacetic Acids
Synthesis of Amino Acid Derivatives from Glycine Derivatives and Ketones/Aldehydes
Conjugation of Two Peptides via Disulfide Linkage
Iridium-Catalyzed Site-Selective Thiolation
Iridium-Photocatalyzed Synthesis of Nonnatural α-Amino Acids
Palladium-Catalyzed Synthesis of Glycopeptides through C–H Activation
Amidation of Amino Acids with 4-[(Fluorosulfonyl)oxy]-benzoic Acid Toward Prodrugs
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Issue 06/2020

Iridium-Catalyzed Synthesis of Quaternary α-Trifluoromethyl α-Amino Acids
Tantalum-Catalyzed Formation of Amide Bonds
Tantalum-or Titanium-Catalyzed Peptide Synthesis
Organocatalytic Synthesis of Axially Chiral Biaryl Amino Acids
Copper-Catalyzed Three-Component Coupling to Form α-Halo β-Amino Acid Derivatives
Copper-Catalyzed Stereoselective Synthesis of α-Amino Acid Precursors
Ytterbium-Catalyzed Synthesis of γ-Amino Acid Derivatives
Asymmetric Mannich-Type Reaction to Access Unnatural Amino Acids
Synthesis of Unnatural α-Amino Acids under Visible-Light Irradiation
Modification of Peptides through C(sp3)–H Alkylation
Catalyst-Free Synthesis of α-Amino Acid Derivatives
Metal-Free Synthesis of α-Amino Acid Derivatives from α-Bromo Amides
Chemical Ligation to Synthesize N-Hydroxy Peptides from O-Acyl Hydroxamic Acids
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Issue 05/2020

Cooperative Catalysis in Amination of β-Hydroxy Carboxylic Acid Esters
Stereoselective Synthesis of N-Allyl Amino Acids by Using Palladium Catalysts
Zinc-Catalyzed Peptide Synthesis by Using a Nicotinate-Directed Protocol
Site-Selective Modification of Selenocystine Peptides
Lewis Acid Catalyzed Synthesis of α-Amino Acid Derivatives
Nickel-Catalyzed Asymmetric Hydrogenation To Afford α-Amino Acid Derivatives
Copper-Catalyzed Functionalization of Tryptophan-Containing Peptides
Synthesis of 3,4-Dihydro-2H-naphtho-1,4-oxazin-2-ones from Amino Acids
Rhodium(III)-Catalyzed C-2 Alkenylation of Tryptophan and Tryptophan-Containing Peptides
Nickel-Catalyzed Synthesis of γ-Amino Acid Derivatives
Organophotocatalytic Synthesis of α-Deuterated α-Amino Acids
Acridine–Peptide Conjugates by Solid-Phase Synthesis
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Issue 04/2020

Boronic Acid Catalyzed Dehydrative Peptide Synthesis
Phase-Transfer-Catalyzed Enantioselective α-Trifluoromethylthiolation
Stereoselective Synthesis of β-Amino Acid Precursors by Organocatalysis
Copper-Catalyzed [3+1] Cycloaddition to Form Substrates for α-Amino Acid Synthesis
Synthesis of Selenocystine-based Peptides through Cyclization Reactions
Copper-Catalyzed Synthesis of Cyanated Peptides
Stereoselective Synthesis of Unnatural α-Amino Acids
Palladium-Catalyzed N-Arylation of Amino Acids and Ketoxime Peptide Ligation
Synthesis of α-Quaternary Chiral Amino Acids by Palladium-Catalyzed Arylation
Synthesis of Fmoc-Aminoacyl‑N‑alkylcysteine Dipeptides by Using the Ugi Reaction
Solid-State Synthesis of a β-Turn Mimetic
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Issue 03/2020

Cyclic Peptides Synthesis with the Assistance of a Removable Activating Group
Synthesis of syn-α,β-Diamino Esters through an Asymmetric Mannich Reaction
Chiral Ammonium Salt Phase-Transfer-Catalyzed Synthesis of Quaternary β2,2-Amino Acids
Hydroperoxide-Mediated Decarboxylative Acylation of Amines with α-Keto Acids
Metal-Free Photochemical Synthesis of α-Amino Acid Derivatives
Synthesis of α-Amino Acid Derivatives from Amines
Synthesis of C-Terminal Glycopeptides
Heterogeneous Catalysis for Amide Bond Formation
Photocatalytic Amide-Bond Formation
Enantioselective Synthesis of α-Aryl-β-amino Acids from N-Boc Imines and Homophthalic Anhydrides
Rhodium-Catalyzed Synthesis of α-Amino Acid Derivatives
Synthesis of α-Amino Acids by One-Pot Oxidation and Transamination of 1,2-Diols
Chlorofusin Cyclic Peptide Synthesis
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Issue 02/2020

Histidine-Specific Modification of Peptides Promoted by Visible Light
DMAP-Catalyzed Peptide Bond Formation by Using Phosphorus Pentoxide
Stereoselective Macrocyclization of Peptides in CyClick Chemistry
Palladium-Catalyzed γ-C(sp3)–H Arylation of Amino Acids and Peptides
Pd-Catalyzed α-Allylation of Trifluoropyruvates to Give α-Allyl(α-trifluoromethyl)amino Acids
Synthesis of α-Amino Acid Derivatives through Palladium-Catalyzed Hydrogenation
Trifluoromethylation on the Side Chain of Tryptophan-Containing Oligopeptides
Palladium-Catalyzed Modification of α-Amino Acid Derivatives and Peptides
Chemical Synthesis of N-Sulfated Amino Acids and Peptides
Peptide Cyclization by Using an α-Azido-N-Fmoc-Amino Acid
Synthesis of Cα-Substituted Proline Derivatives Based on Memory of Chirality
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Issue 01/2020

Palladium-Catalyzed C–N Bond Formation of Halotryptophans
Phosphinobenzenethiol-Induced Ligation of Amino Acid Thioesters with 2-Azido-N-benzylacetamide
Organocatalytic Synthesis of α-Hydroxy/Keto-β-Amino Acid Analogues
β-Mercaptan-Assisted Chemical Ligation of Lysine-Containing Peptides
Pd-Catalyzed Functionalization of Peptides and Macrocyclization of Biaryl-Bridged Peptides
Palladium-Catalyzed Selective C–H Olefination of Tryptophan Residues in Peptides
Synthesis of γ-Amino Acid Derivatives from Cyclopropanes
Organocatalyzed Halolactonization of Dienoic Acids
Synthesis of γ-Azido Amino Acid Derivatives
All PDFs of this category

Issue 12/2019

Design of an Organocatalyst for Peptide Synthesis
Stereodivergent Synthesis of α-Amino Acids by Palladium and Copper Catalysis
Chemical Ligation of Ketoxime Peptides Derived from N-Aryl Peptides and Alkoxyamines
Synthesis of Dehydroamino Acids through Stereospecific Elimination
One-Pot Chemical Synthesis of Proteins by Copper-Mediated Selenazolidine Deprotection
Enzymatic Coupling of Nitroalkanes with Serine
A Straightforward Route to Various N-Trifluoromethylated Compounds
Synthesis of γ-Amino Acid Derivatives from Cyclopropanes with a Chiral Heterobimetallic Catalyst
Nickel-Catalyzed Deaminative Coupling of Pyridinium Salts Derived from Amino Acids
Picolinamide-Directed Palladium-Catalyzed Arylation of Nonactivated C(sp3)–H Bonds
Synthesis of γ-Amino Acid Derivatives through a Radical Process
Metal-Free Three-Component Synthesis of β-Lactams
All PDFs of this category

Issue 11/2019

Synthesis of Cyclic and Bicyclic Peptides
Palladium-Catalyzed Conversion of Phenyl Aspartates into Ketones
Ruthenium-Catalyzed C–H Alkylation of Resin-Attached Tryptophan
Asymmetric Hydrogenation of β-Aminoacrylates to β-Amino Acid Derivatives
Palladium-Catalyzed Acylation of Phenylalanine-Containing Peptides
Palladium-Catalyzed Arylation of Sulfonamide-Containing Peptides
Synthesis of Diazirines from Amino Acids by Using Phenyliodonium Diacetate
Synthesis of Dehydroamino Acid Containing Peptides
Synthesis of Benzotriazole-Derived α-Amino Acids
Synthesis of Activated Amides and Directed C(sp3)–H Arylation
Peptide Nanoassemblies Promote Enantioselective Hydrogenation
All PDFs of this category

Issue 10/2019

Modified KAHA Ligation for Protein Synthesis
Selenium-Auxiliary-Mediated Chemical Ligation
Sulfide-Mediated Peptide Ligation in Water
Palladium-Catalyzed Hydrogenation of β-Fluoroalkyl β-Amino Acrylic Acids
Stereoselective Synthesis of α-Allyl Amino Esters by Organocatalysis
Formamide-Catalyzed Efficient Amidation and Esterification
Atroposelective Couplings of Indoles with Amino Acid Derivatives
Synthesis of Selenocysteine-Based Peptides
Staudinger Ligation for the Synthesis of Peptides
Cooperative Catalysis for Asymmetric Multicomponent Reactions
Removal of Aminoquinoline Auxiliary from Protected α-Amino Acids
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Issue 09/2019

Palladium-Catalyzed Synthesis of Cyclophane-Braced Peptide Macrocycles
Cyclic β-Amino Acid Synthesis by Rhodium Catalysis
Synthesis of Cyclic Peptides by the Peptide Claisen Rearrangement
Manganese(I)-Catalyzed C–H Glycosylation of Amino Acids and Peptides
Enantioselective Synthesis of β-Amino Alcohols by Palladium Catalysis
Synthesis of β2-Aryl Amino Acids with Palladium Catalysts
Tandem N,N-Dialkylation Reaction to Synthesize α-Amino Acid Derivatives
Reductive Radical Cyclization of Tyrosine and Phenylalanine with Alkenes
Synthesis of β-Nitro α-Amino Carboxylic Acids by an Aza-Henry Reaction
Biocompatible Macrocyclization of Peptides
Palladium-Catalyzed Cross-Coupling for the Synthesis of Fluorinated Amino Acids
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Issue 08/2019

Organcatalytic Transamination for the Synthesis of α-Amino Acids
One-Pot Four-Component Strategy for Electrophilic Fluorination
Site-Selective Reduction of Cyclosporine A by Borane Catalysis
Palladium-Catalyzed β-C–H Arylation of N-Methylated Peptides
Synthesis of Rigidified Cyclic Peptides by Ring-Closing Metathesis
Azotide Ligands for Hetero-Diels–Alder Reactions
Synthesis of N-Terminal Cysteinyl Thioesters
Nickel-Catalyzed Synthesis of Amides from Methyl Esters
Pd-Catalyzed Arylation of α-Amino Esters with Diaryliodonium Triflates
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Issue 07/2019

Synthesis of Disubstituted Peptidoisoxazoles
Organcatalysis for the Synthesis of α,α-Difluoro-β-Amino Amides
Photoredox-Catalyzed Decarboxylative Alkynylation of Peptides
Cooperative Catalysis for Enantioselective α-Allylic Alkylation
Peptide C(sp2)–O Cross-Coupling by Nickel/Photoredox Dual Catalysis
Photocatalyzed Efficient Synthesis of C-Glycoamino Acids
Efficient Peptide Coupling for the Total Synthesis of Echinocandins
Zn/Cu(OTf)2-Mediated 1,4-Addition of Alkyl/Aryl Halides to Dehydroalanine
β-Aryl-β-pyrazolyl α-Amino Acid Synthesis by Copper Catalysis
Copper-Catalyzed 1,4-Reduction of N-Aryl β-Enamino Esters
Total Synthesis of the Cyclic Tetrapeptide Pseudoxylallemycin A
Construction of Peptide Linkages by Using Sulfuryl Fluoride
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Issue 06/2019

Amide N–H Arylation of Pyroglutamate–Histidine Promoted by Nickel(II) Acetate
Oligomerization of Amino Thioacids by Simple Oxidation
Palladium-Catalyzed Site-Selective γ-C(sp3)–H Silylation of Peptides
Ruthenium-Catalyzed Dynamic Kinetic Resolution–Asymmetric Hydrogenation
One-Pot Reaction of Amino Acid Esters with Isocyanates and α-Bromo Ketones
Palladium-Catalyzed Insertion of Carbenoids into N,O-Aminals
Synthesis of the C-Terminal Macrocycle of Asperipin-2a
Peptide Ligation Mediated by a Removable Acyl Transfer Auxiliary
Thiourea/Boronic Acid Catalyzed Asymmetric Aza-Michael Reaction
Silver(I)-Promoted Macrocyclization of Linear Peptides
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Issue 05/2019

Pd-Catalyzed Oxazoloisoindolinone Synthesis from N-Benzoyl-α-Amino Acids
C-Terminal Elongation of Dipeptide Isopropenyl Esters
Efficient Macrocyclization of Small Peptides
Cleavage of Fmoc Groups with Sodium Hydroxide in 2-Methyltetrahydrofuran–Methanol
Copper-Catalyzed Multicomponent Synthesis of Quaternary α-Amino Esters
Thiourea-Catalyzed Asymmetric Mannich Reaction
Synthesis of Peptides by Using Recombinant Proteins
Chemoselective Ligation by Using an Adipic Acid Dihydrazide Crosslinker
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Issue 04/2019

O-Glycosylation of Unprotected Peptides
One-Pot Peptide Modifications Using the MeDbz Linker
Synthesis of Free α-Amino Acids from 1,2-Diols
Two-Step Strategy for Thioamide Bond Formation by Using an Ynamide
Photoredox-Catalyzed α-Fluoro-α-Amino Acid Synthesis
Photoredox Catalysis with Amino Acid- and Peptide-Derived Katritzky Salts
Petasis Reaction for Late-Stage Functionalization of Peptides
Photocatalytic Decarboxylative C(sp3)–H Alkylation of Glycine or Peptides
Manganese-Catalyzed Synthesis of Acylic, Hybrid, and Stapled Peptides
Palladium-Catalyzed Asymmetric Aminomethylation
Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation
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Issue 03/2019

Synthesis of Cyclophane-Braced Peptide Macrocycles
Preparation of 2-Aminocyclopropanecarboxylic Acid-Derived Peptides
Palladium-Catalyzed C–H Functionalization of N-Methyl Amino Acids
Cyclocarbonylation of Aromatic α-Amino Acids Promoted by Potassium Iodide
Cobalt-Catalyzed C–H Alkylation of Tryptophan Derivatives
Palladium-Catalyzed Olefination of Phenylalanine Residues in Peptides
Unnatural Amino Acids and Peptides Synthesis by Photoredox Catalysis
Palladium-Catalyzed Thioglycoconjugation of Iodoaryl Peptides and Amino Acids
BINOL-Catalyzed Propargyl- or Allylboration of Hydrazono Esters
Chemical Ligation of Unprotected Peptide Segments
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Issue 02/2019

A Catalytic One-Step Synthesis of Peptide Thioacids
Extension of Native Chemical Ligation
Native Chemical Ligation by Microflow Chemistry
(4-Mercaptophenyl)acetic Acid-Promoted One-Pot Multiple Peptide Ligation
Palladium-Catalyzed C(sp3)–H Activation of Amino Acids and Peptide
Synthesis of Palmitoylated Sonic Hedgehog by Native Chemical Ligation
Nickel-Catalyzed Innate Radical Coupling Reaction
Copper-Catalyzed C(sp3)–H Direct Fluorination of Amino Acids
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Issue 01/2019

Stereoselective Synthesis of α-Aryl Amino Acids
Peptide Macrocyclization by Palladium-Catalyzed δ-C(sp2)–H Olefination
Synthesis of Backbone-Engineered HIV Protease by Selective Chemical Ligation
Direct Peptide Synthesis via N-Acyl Imidazolium Intermediates
2,4-Bis(trifluoromethyl)phenylboronic Acid Catalyzed Amidation
Modified Yamaguchi Reagent Mediated Coupling Reactions
Tris(2,2,2-Trifluoroethyl) Borate Catalyzed, Protecting-Group-Free Amidation
Native Chemical Ligation by Flow Chemistry
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